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- W1968045410 abstract "Isotopic techniques were used to test the hypothesis that exercise and nitric oxide synthase (NOS) inhibition have distinct effects on tissue-specific fatty acid and glucose uptakes in a conscious, chronically catheterized mouse model. Uptakes were measured using the radioactive tracers 125 I-labeled β-methyl- p-iodophenylpentadecanoic acid (BMIPP) and deoxy-[2- 3 H]glucose (DG) during treadmill exercise with and without inhibition of NOS. [ 125 I]BMIPP uptake at rest differed substantially among tissues with the highest levels in heart. With exercise, [ 125 I]BMIPP uptake increased in both heart and skeletal muscles. In sedentary mice, NOS inhibition induced by nitro-l-arginine methyl ester (l-NAME) feeding increased heart and soleus [ 125 I]BMIPP uptake. In contrast, exercise, but not l-NAME feeding, resulted in increased heart and skeletal muscle [2- 3 H]DG uptake. Significant interactions were not observed in the effects of combined exercise and l-NAME feeding on [ 125 I]BMIPP and [2- 3 H]DG uptakes. In the conscious mouse, exercise and NOS inhibition produce distinct patterns of tissue-specific fatty acid and glucose uptake; NOS is not required for important components of exercise-associated metabolic signaling, or other mechanisms compensate for the absence of this regulatory mechanism." @default.
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- W1968045410 date "2002-07-01" @default.
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- W1968045410 title "Contrasting effects of exercise and NOS inhibition on tissue-specific fatty acid and glucose uptake in mice" @default.
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- W1968045410 doi "https://doi.org/10.1152/ajpendo.00545.2001" @default.
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