Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968045861> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W1968045861 endingPage "128" @default.
- W1968045861 startingPage "122" @default.
- W1968045861 abstract "<i>Objectives:</i> This study was designed to determine whether the complement (C) system may be involved in the febrile response to zymosan (Zym), a glycan derived from yeast cell walls. <i>Methods:</i> Cobra venom factor (CVF) at 100 U/animal or its vehicle, pyrogen-free saline (PFS), was injected intravenously (i.v.) into guinea pigs to deplete serum C. Eighteen hours later, a low or high dose of Zym or its vehicle, PFS, was administered i.v. or intraperitoneally (i.p.) to these animals. The core temperature (T<sub>c</sub>) was measured continuously by thermocouples. Serum C levels were determined by sheep erythrocyte hemolytic assay. <i>Results:</i> Zym at 1 mg/kg caused a 1°C T<sub>c</sub> rise that was not significantly affected by CVF pretreatment. However, CVF-induced hypocomplementation converted the T<sub>c</sub> fall (∼1.2°C) produced by 100 mg/kg of Zym i.p. into a 1°C T<sub>c</sub> rise. Similarly, CVF pretreatment did not affect the T<sub>c</sub> rise caused by 0.5 mg/kg of Zym i.v., but converted the T<sub>c</sub> fall induced by 25 mg/kg i.v. into a 1°C T<sub>c</sub> rise. A separate experiment showed that 25, but not 0.5 mg/kg of Zym i.v., decreased serum C by 34% in 15 min; C did not recover over the next 6 h. A second i.v. injection of 25 mg Zym/kg 210 min later, when the T<sub>c</sub> had recovered but the serum C had not, yielded a smaller and briefer T<sub>c</sub> fall. <i>Conclusion:</i> These results suggest that Zym is inherently pyrogenic, but this effect is manifested only when the dose of zymosan is too small to activate C or when C has been reduced by prior activation." @default.
- W1968045861 created "2016-06-24" @default.
- W1968045861 creator A5009386196 @default.
- W1968045861 creator A5077780769 @default.
- W1968045861 creator A5084510530 @default.
- W1968045861 date "2002-01-01" @default.
- W1968045861 modified "2023-10-15" @default.
- W1968045861 title "Thermal Response to Zymosan: The Differential Role of Complement" @default.
- W1968045861 cites W2001286887 @default.
- W1968045861 cites W2107865650 @default.
- W1968045861 cites W2145399009 @default.
- W1968045861 doi "https://doi.org/10.1159/000065187" @default.
- W1968045861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12372985" @default.
- W1968045861 hasPublicationYear "2002" @default.
- W1968045861 type Work @default.
- W1968045861 sameAs 1968045861 @default.
- W1968045861 citedByCount "9" @default.
- W1968045861 countsByYear W19680458612014 @default.
- W1968045861 countsByYear W19680458612017 @default.
- W1968045861 countsByYear W19680458612020 @default.
- W1968045861 crossrefType "journal-article" @default.
- W1968045861 hasAuthorship W1968045861A5009386196 @default.
- W1968045861 hasAuthorship W1968045861A5077780769 @default.
- W1968045861 hasAuthorship W1968045861A5084510530 @default.
- W1968045861 hasConcept C111684460 @default.
- W1968045861 hasConcept C153911025 @default.
- W1968045861 hasConcept C185592680 @default.
- W1968045861 hasConcept C202751555 @default.
- W1968045861 hasConcept C203014093 @default.
- W1968045861 hasConcept C2778870864 @default.
- W1968045861 hasConcept C55493867 @default.
- W1968045861 hasConcept C71924100 @default.
- W1968045861 hasConcept C86803240 @default.
- W1968045861 hasConcept C8891405 @default.
- W1968045861 hasConceptScore W1968045861C111684460 @default.
- W1968045861 hasConceptScore W1968045861C153911025 @default.
- W1968045861 hasConceptScore W1968045861C185592680 @default.
- W1968045861 hasConceptScore W1968045861C202751555 @default.
- W1968045861 hasConceptScore W1968045861C203014093 @default.
- W1968045861 hasConceptScore W1968045861C2778870864 @default.
- W1968045861 hasConceptScore W1968045861C55493867 @default.
- W1968045861 hasConceptScore W1968045861C71924100 @default.
- W1968045861 hasConceptScore W1968045861C86803240 @default.
- W1968045861 hasConceptScore W1968045861C8891405 @default.
- W1968045861 hasIssue "2" @default.
- W1968045861 hasLocation W19680458611 @default.
- W1968045861 hasLocation W19680458612 @default.
- W1968045861 hasOpenAccess W1968045861 @default.
- W1968045861 hasPrimaryLocation W19680458611 @default.
- W1968045861 hasRelatedWork W1531601525 @default.
- W1968045861 hasRelatedWork W2026099298 @default.
- W1968045861 hasRelatedWork W2122558851 @default.
- W1968045861 hasRelatedWork W2606230654 @default.
- W1968045861 hasRelatedWork W2607424097 @default.
- W1968045861 hasRelatedWork W2748952813 @default.
- W1968045861 hasRelatedWork W2899084033 @default.
- W1968045861 hasRelatedWork W2948807893 @default.
- W1968045861 hasRelatedWork W4387497383 @default.
- W1968045861 hasRelatedWork W2778153218 @default.
- W1968045861 hasVolume "10" @default.
- W1968045861 isParatext "false" @default.
- W1968045861 isRetracted "false" @default.
- W1968045861 magId "1968045861" @default.
- W1968045861 workType "article" @default.