FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968046543> ?p ?o ?g. }

• W1968046543 endingPage "1994" @default.
• W1968046543 startingPage "1983" @default.
• W1968046543 abstract "Analogues of endomorphin-2 (EM-2: Tyr-Pro-Phe-Phe-NH(2)) (1) were designed to examine the importance of each residue on mu-opioid receptor interaction. Replacement of Tyr(1) by 2',6'-dimethyl-L-tyrosine (Dmt) (9-12) exerted profound effects: [Dmt(1)]EM-2 (9) elevated mu-opioid affinity 4.6-fold (K(i mu=0.15 nM) yet selectivity fell 330-fold as delta-affinity rose (K(i)delta=28.2 nM). This simultaneous increased mu- and delta-receptor bioactivities resulted in dual agonism (IC(50)=0.07 and 1.87 nM, respectively). While substitution of Phe(4) by a phenethyl group (4) decreased mu affinity (K(i)mu=13.3 nM), the same derivative containing Dmt (12) was comparable to EM-2 but also acquired weak delta antagonism (pA(2)=7.05). 1H NMR spectroscopy revealed a trans configuration (1:2 to 1:3, cis/trans) in the Tyr-Pro amide bond, but a cis configuration (5:3 to 13:7, cis/trans) with Dmt-Pro analogues." @default.
• W1968046543 created "2016-06-24" @default.
• W1968046543 creator A5011165278 @default.
• W1968046543 creator A5011730338 @default.
• W1968046543 creator A5015126934 @default.
• W1968046543 creator A5018271040 @default.
• W1968046543 creator A5019064611 @default.
• W1968046543 creator A5022567148 @default.
• W1968046543 creator A5026015819 @default.
• W1968046543 creator A5030809281 @default.
• W1968046543 creator A5043263125 @default.
• W1968046543 creator A5057689563 @default.
• W1968046543 creator A5085595471 @default.
• W1968046543 date "2003-05-01" @default.
• W1968046543 modified "2023-09-23" @default.
• W1968046543 title "Structural studies of [2′,6′-dimethyl-l-tyrosine1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond" @default.
• W1968046543 cites W1965534248 @default.
• W1968046543 cites W1966654056 @default.
• W1968046543 cites W1974929066 @default.
• W1968046543 cites W1975262853 @default.
• W1968046543 cites W1980281407 @default.
• W1968046543 cites W1981586790 @default.
• W1968046543 cites W1986751279 @default.
• W1968046543 cites W1994104893 @default.
• W1968046543 cites W1997780054 @default.
• W1968046543 cites W2008602694 @default.
• W1968046543 cites W2010051841 @default.
• W1968046543 cites W2014371883 @default.
• W1968046543 cites W2020366719 @default.
• W1968046543 cites W2022441490 @default.
• W1968046543 cites W2031468509 @default.
• W1968046543 cites W2032761582 @default.
• W1968046543 cites W2040310294 @default.
• W1968046543 cites W2051612811 @default.
• W1968046543 cites W2056714297 @default.
• W1968046543 cites W2061661291 @default.
• W1968046543 cites W2065458147 @default.
• W1968046543 cites W2075811628 @default.
• W1968046543 cites W2086876254 @default.
• W1968046543 cites W2087457307 @default.
• W1968046543 cites W2094270034 @default.
• W1968046543 cites W2159129984 @default.
• W1968046543 cites W2161909946 @default.
• W1968046543 cites W2334418325 @default.
• W1968046543 cites W2952084650 @default.
• W1968046543 cites W4294250607 @default.
• W1968046543 doi "https://doi.org/10.1016/s0968-0896(03)00068-3" @default.
• W1968046543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12670649" @default.
• W1968046543 hasPublicationYear "2003" @default.
• W1968046543 type Work @default.
• W1968046543 sameAs 1968046543 @default.
• W1968046543 citedByCount "53" @default.
• W1968046543 countsByYear W19680465432012 @default.
• W1968046543 countsByYear W19680465432013 @default.
• W1968046543 countsByYear W19680465432014 @default.
• W1968046543 countsByYear W19680465432015 @default.
• W1968046543 countsByYear W19680465432016 @default.
• W1968046543 countsByYear W19680465432019 @default.
• W1968046543 countsByYear W19680465432020 @default.
• W1968046543 countsByYear W19680465432023 @default.
• W1968046543 crossrefType "journal-article" @default.
• W1968046543 hasAuthorship W1968046543A5011165278 @default.
• W1968046543 hasAuthorship W1968046543A5011730338 @default.
• W1968046543 hasAuthorship W1968046543A5015126934 @default.
• W1968046543 hasAuthorship W1968046543A5018271040 @default.
• W1968046543 hasAuthorship W1968046543A5019064611 @default.
• W1968046543 hasAuthorship W1968046543A5022567148 @default.
• W1968046543 hasAuthorship W1968046543A5026015819 @default.
• W1968046543 hasAuthorship W1968046543A5030809281 @default.
• W1968046543 hasAuthorship W1968046543A5043263125 @default.
• W1968046543 hasAuthorship W1968046543A5057689563 @default.
• W1968046543 hasAuthorship W1968046543A5085595471 @default.
• W1968046543 hasConcept C112887158 @default.
• W1968046543 hasConcept C118792377 @default.
• W1968046543 hasConcept C141087196 @default.
• W1968046543 hasConcept C14397066 @default.
• W1968046543 hasConcept C161790260 @default.
• W1968046543 hasConcept C170493617 @default.
• W1968046543 hasConcept C178790620 @default.
• W1968046543 hasConcept C185592680 @default.
• W1968046543 hasConcept C2776885963 @default.
• W1968046543 hasConcept C2778439535 @default.
• W1968046543 hasConcept C2779281246 @default.
• W1968046543 hasConcept C31684184 @default.
• W1968046543 hasConcept C32909587 @default.
• W1968046543 hasConcept C55493867 @default.
• W1968046543 hasConcept C71240020 @default.
• W1968046543 hasConceptScore W1968046543C112887158 @default.
• W1968046543 hasConceptScore W1968046543C118792377 @default.
• W1968046543 hasConceptScore W1968046543C141087196 @default.
• W1968046543 hasConceptScore W1968046543C14397066 @default.
• W1968046543 hasConceptScore W1968046543C161790260 @default.
• W1968046543 hasConceptScore W1968046543C170493617 @default.
• W1968046543 hasConceptScore W1968046543C178790620 @default.
• W1968046543 hasConceptScore W1968046543C185592680 @default.
• W1968046543 hasConceptScore W1968046543C2776885963 @default.
• W1968046543 hasConceptScore W1968046543C2778439535 @default.
• W1968046543 hasConceptScore W1968046543C2779281246 @default.

• next