FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968048003> ?p ?o ?g. }

• W1968048003 endingPage "S277" @default.
• W1968048003 startingPage "S276" @default.
• W1968048003 abstract "Randomized trials support the role of boost irradiation following breast-conserving surgery and radiotherapy (RT) in the management of early stage breast cancer. During CT-based treatment planning, boost planning often utilizes the CT obtained prior to the initiation of whole breast RT, approximately 4–6 weeks before the boost. Breast swelling can occur following whole breast RT, which may affect the localization of the tumor bed. However, the extent of volumetric changes following breast irradiation has not previously been reported. The aims of this study were (1) to determine changes in breast and biopsy cavity volumes following whole breast irradiation prior to initiation of the boost and (2) to use CT-based metrics to determine the adequacy of using the surgical scar to guide boost field placement. Twenty-six consecutively treated women with Stages 0-II breast cancer underwent CT planning to the breast in two sessions. CT1 was performed for treatment planning of the intact breast. CT2 was performed within a week prior to start of the boost, after delivering 32–48 Gy to the whole breast. After obtaining consent from the IRB, breast volumes were delineated on CT1 based on clinical borders, using catheters placed 1.0–1.5 cm beyond palpable breast tissue. Using image fusion tools, the catheters were superimposed on CT2. Contouring of biopsy cavities was guided by surgical clips, hematoma, and/or surgical changes, depending on which indicated greatest volume. Hypothetical boost treatment plans were generated using a constant margin of 3 cm around the surgical scar. Dose-volume histograms for the biopsy cavities were generated and analyzed for adequacy of coverage. Patient weights ranged from 98.8 to 263.5 lbs (median = 159.0). The mean breast volumes prior to and following intact breast irradiation were 755 cc (560 to 950 cc, all ranges represent 95%CI) and 736 cc (555 to 917 cc), respectively. This represents a mean change of -0.026% (p = 0.07). The mean biopsy cavity volumes prior to and following intact breast irradiation were 32.0 cc (24.6 to 39.4 cc) and 24.5 cc (17.7 to 31.2 cc), respectively. This represents a mean change of -24.7% (p < 0.0003). In 24/26 patients, the biopsy cavity volume decreased following intact breast irradiation. The relative reduction in biopsy cavity volume demonstrated an inversely proportional trend when compared to time elapsed since most recent surgical excision (r = 0.47). This relative reduction did not significantly correlate with breast volume and prior chemotherapy. When electron boost volumes were defined by the surgical scar on CT1, the mean percentages of volume encompassed within 90%, 80%, and 50% isodose lines were 77.2% (70.1 to 84.3%), 86.8% (81.7 to 92.0%), and 94.9% (92.1 to 97.8%), respectively. Those for CT2 were 74.6% (65.1 to 84.0%), 86.7% (79.8 to 93.6%), and 94.6% (89.8 to 99.4%), respectively. There were no statistically significant differences in coverage within these isodose lines between CT1 and CT2 (p = 0.37, 0.93, and 0.83, respectively). When the boost was planned on CT2 using only the surgical scar, the minimum dose treated to the biopsy cavity was significantly lower if the cavity was located in the inner quadrants (33.3% of prescribed dose) compared to the outer quadrants (68.2%) of the breast (p < 0.02). Larger biopsy cavities (> 20 cc) had significantly lower minimum doses treated to the biopsy cavity (36.5% of prescribed dose) than smaller ones (63.9%, p < 0.05). We did not observe a significant change in breast volume following whole breast RT prior to the boost. The majority of CT scans did, however, demonstrate a decrease in biopsy cavity volumes, suggesting that a boost plan generated from the initial breast scan provides adequate coverage of the tumor bed. The use of the surgical scar as a guide for boost treatment planning was often inadequate, especially for biopsy cavities of large volume or in the inner quadrants. These findings may help guide clinicians in the design of CT-planned boost fields" @default.
• W1968048003 created "2016-06-24" @default.
• W1968048003 creator A5005989034 @default.
• W1968048003 creator A5027798049 @default.
• W1968048003 creator A5036540537 @default.
• W1968048003 creator A5080697114 @default.
• W1968048003 date "2004-09-01" @default.
• W1968048003 modified "2023-10-14" @default.
• W1968048003 title "Planning the breast boost: Influence of volumetric changes in the biopsy cavity and surgical scar location following whole breast irradiation" @default.
• W1968048003 doi "https://doi.org/10.1016/j.ijrobp.2004.07.062" @default.
• W1968048003 hasPublicationYear "2004" @default.
• W1968048003 type Work @default.
• W1968048003 sameAs 1968048003 @default.
• W1968048003 citedByCount "0" @default.
• W1968048003 crossrefType "journal-article" @default.
• W1968048003 hasAuthorship W1968048003A5005989034 @default.
• W1968048003 hasAuthorship W1968048003A5027798049 @default.
• W1968048003 hasAuthorship W1968048003A5036540537 @default.
• W1968048003 hasAuthorship W1968048003A5080697114 @default.
• W1968048003 hasBestOaLocation W19680480031 @default.
• W1968048003 hasConcept C121608353 @default.
• W1968048003 hasConcept C126322002 @default.
• W1968048003 hasConcept C126838900 @default.
• W1968048003 hasConcept C127413603 @default.
• W1968048003 hasConcept C141071460 @default.
• W1968048003 hasConcept C146357865 @default.
• W1968048003 hasConcept C151730666 @default.
• W1968048003 hasConcept C199639397 @default.
• W1968048003 hasConcept C201645570 @default.
• W1968048003 hasConcept C2775934546 @default.
• W1968048003 hasConcept C2777517664 @default.
• W1968048003 hasConcept C2777704003 @default.
• W1968048003 hasConcept C2777757722 @default.
• W1968048003 hasConcept C2779104521 @default.
• W1968048003 hasConcept C2779572924 @default.
• W1968048003 hasConcept C2780472235 @default.
• W1968048003 hasConcept C2781467025 @default.
• W1968048003 hasConcept C509974204 @default.
• W1968048003 hasConcept C530470458 @default.
• W1968048003 hasConcept C71924100 @default.
• W1968048003 hasConcept C86803240 @default.
• W1968048003 hasConceptScore W1968048003C121608353 @default.
• W1968048003 hasConceptScore W1968048003C126322002 @default.
• W1968048003 hasConceptScore W1968048003C126838900 @default.
• W1968048003 hasConceptScore W1968048003C127413603 @default.
• W1968048003 hasConceptScore W1968048003C141071460 @default.
• W1968048003 hasConceptScore W1968048003C146357865 @default.
• W1968048003 hasConceptScore W1968048003C151730666 @default.
• W1968048003 hasConceptScore W1968048003C199639397 @default.
• W1968048003 hasConceptScore W1968048003C201645570 @default.
• W1968048003 hasConceptScore W1968048003C2775934546 @default.
• W1968048003 hasConceptScore W1968048003C2777517664 @default.
• W1968048003 hasConceptScore W1968048003C2777704003 @default.
• W1968048003 hasConceptScore W1968048003C2777757722 @default.
• W1968048003 hasConceptScore W1968048003C2779104521 @default.
• W1968048003 hasConceptScore W1968048003C2779572924 @default.
• W1968048003 hasConceptScore W1968048003C2780472235 @default.
• W1968048003 hasConceptScore W1968048003C2781467025 @default.
• W1968048003 hasConceptScore W1968048003C509974204 @default.
• W1968048003 hasConceptScore W1968048003C530470458 @default.
• W1968048003 hasConceptScore W1968048003C71924100 @default.
• W1968048003 hasConceptScore W1968048003C86803240 @default.
• W1968048003 hasIssue "1" @default.
• W1968048003 hasLocation W19680480031 @default.
• W1968048003 hasOpenAccess W1968048003 @default.
• W1968048003 hasPrimaryLocation W19680480031 @default.
• W1968048003 hasRelatedWork W2063475905 @default.
• W1968048003 hasRelatedWork W2074004671 @default.
• W1968048003 hasRelatedWork W2318436276 @default.
• W1968048003 hasRelatedWork W2342057803 @default.
• W1968048003 hasRelatedWork W2359897561 @default.
• W1968048003 hasRelatedWork W2368745722 @default.
• W1968048003 hasRelatedWork W2413263973 @default.
• W1968048003 hasRelatedWork W2427775871 @default.
• W1968048003 hasRelatedWork W2804733674 @default.
• W1968048003 hasRelatedWork W3180416178 @default.
• W1968048003 hasVolume "60" @default.
• W1968048003 isParatext "false" @default.
• W1968048003 isRetracted "false" @default.
• W1968048003 magId "1968048003" @default.
• W1968048003 workType "article" @default.