Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968049374> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1968049374 endingPage "69" @default.
- W1968049374 startingPage "63" @default.
- W1968049374 abstract "Mitochondrial, microsomal and soluble fractions separated from the guinea pig taenia and from the dog longitudinal smooth muscle were used as phosphodiesterase preparations. Each preparation had low and high Km values, indicating the existence of at least two kinds of phosphodiesterase. Papaverine and Aspa-minol (1, 1-diphenyl-3-piperidinobutanol hydrochloride), hydralazine, caffeine Na benzoate and aminophylline were used as test drugs. Aspaminol had little inhibitory effect on phosphodiesterase. Ki value of papaverine almost equalled the concentration (M) which was necessary to produce 50% relaxation. Relaxation of the guinea pig taenia by papaverine was preceded by an increase of intracellular cyclic AMP. Therefore, the action of papaverine is likely to be mediated by an increase in cyclic AMP, which is caused by inhibition of the phosphodiesterase-catalyzed breakdown of cyclic AMP. There was little correlation between relaxing activities of the drugs used and their antiphosphodiesterase activities. Relaxation of the smooth muscle induced by the smooth muscle relaxants excepting papaverine is not due to inhibition of phosphodiesterase." @default.
- W1968049374 created "2016-06-24" @default.
- W1968049374 creator A5014685914 @default.
- W1968049374 creator A5074204610 @default.
- W1968049374 creator A5083042455 @default.
- W1968049374 date "1975-01-01" @default.
- W1968049374 modified "2023-10-18" @default.
- W1968049374 title "ANTIPHOSPHODIESTERASE ACTIVITY AND NONSPECIFIC SMOOTH MUSCLE RELAXATION TESTED ON INTESTINAL SMOOTH MUSCLES" @default.
- W1968049374 cites W1590941707 @default.
- W1968049374 cites W1996466550 @default.
- W1968049374 cites W2010486944 @default.
- W1968049374 cites W2017491649 @default.
- W1968049374 cites W2035923870 @default.
- W1968049374 cites W2046953488 @default.
- W1968049374 cites W2082027079 @default.
- W1968049374 cites W4241332557 @default.
- W1968049374 cites W4243447552 @default.
- W1968049374 cites W4255596969 @default.
- W1968049374 doi "https://doi.org/10.1254/jjp.25.63" @default.
- W1968049374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/168424" @default.
- W1968049374 hasPublicationYear "1975" @default.
- W1968049374 type Work @default.
- W1968049374 sameAs 1968049374 @default.
- W1968049374 citedByCount "18" @default.
- W1968049374 crossrefType "journal-article" @default.
- W1968049374 hasAuthorship W1968049374A5014685914 @default.
- W1968049374 hasAuthorship W1968049374A5074204610 @default.
- W1968049374 hasAuthorship W1968049374A5083042455 @default.
- W1968049374 hasBestOaLocation W19680493741 @default.
- W1968049374 hasConcept C126322002 @default.
- W1968049374 hasConcept C134018914 @default.
- W1968049374 hasConcept C181199279 @default.
- W1968049374 hasConcept C185592680 @default.
- W1968049374 hasConcept C2776202631 @default.
- W1968049374 hasConcept C2776952824 @default.
- W1968049374 hasConcept C2778095195 @default.
- W1968049374 hasConcept C2778500429 @default.
- W1968049374 hasConcept C2778815084 @default.
- W1968049374 hasConcept C2781084959 @default.
- W1968049374 hasConcept C2992204568 @default.
- W1968049374 hasConcept C2992686903 @default.
- W1968049374 hasConcept C55493867 @default.
- W1968049374 hasConcept C62826618 @default.
- W1968049374 hasConcept C71924100 @default.
- W1968049374 hasConcept C86803240 @default.
- W1968049374 hasConcept C98274493 @default.
- W1968049374 hasConceptScore W1968049374C126322002 @default.
- W1968049374 hasConceptScore W1968049374C134018914 @default.
- W1968049374 hasConceptScore W1968049374C181199279 @default.
- W1968049374 hasConceptScore W1968049374C185592680 @default.
- W1968049374 hasConceptScore W1968049374C2776202631 @default.
- W1968049374 hasConceptScore W1968049374C2776952824 @default.
- W1968049374 hasConceptScore W1968049374C2778095195 @default.
- W1968049374 hasConceptScore W1968049374C2778500429 @default.
- W1968049374 hasConceptScore W1968049374C2778815084 @default.
- W1968049374 hasConceptScore W1968049374C2781084959 @default.
- W1968049374 hasConceptScore W1968049374C2992204568 @default.
- W1968049374 hasConceptScore W1968049374C2992686903 @default.
- W1968049374 hasConceptScore W1968049374C55493867 @default.
- W1968049374 hasConceptScore W1968049374C62826618 @default.
- W1968049374 hasConceptScore W1968049374C71924100 @default.
- W1968049374 hasConceptScore W1968049374C86803240 @default.
- W1968049374 hasConceptScore W1968049374C98274493 @default.
- W1968049374 hasIssue "1" @default.
- W1968049374 hasLocation W19680493741 @default.
- W1968049374 hasLocation W19680493742 @default.
- W1968049374 hasOpenAccess W1968049374 @default.
- W1968049374 hasPrimaryLocation W19680493741 @default.
- W1968049374 hasRelatedWork W1594487851 @default.
- W1968049374 hasRelatedWork W1968049374 @default.
- W1968049374 hasRelatedWork W1987863941 @default.
- W1968049374 hasRelatedWork W2028134886 @default.
- W1968049374 hasRelatedWork W2039795602 @default.
- W1968049374 hasRelatedWork W2106068640 @default.
- W1968049374 hasRelatedWork W2300267003 @default.
- W1968049374 hasRelatedWork W2401361643 @default.
- W1968049374 hasRelatedWork W2737045746 @default.
- W1968049374 hasRelatedWork W4253039020 @default.
- W1968049374 hasVolume "25" @default.
- W1968049374 isParatext "false" @default.
- W1968049374 isRetracted "false" @default.
- W1968049374 magId "1968049374" @default.
- W1968049374 workType "article" @default.