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- W1968050381 abstract "FRESH WHOLE BLOOD has been used for exchange transfusion because, as compared to the use of packed red cells, the greater amount of plasma (albumin) allows removal of more bilirubin. However, in the past decade two changes have altered this situation: the survival of smaller and sicker infants and the increased availability of blood components. Modern therapy now requires keeping a newborn infant's hematocrit above certain levels depending on gestational age and clinical condition, l At least two reasons are give n for these recommendations. (1) Compared to adults, the newborn infant has an increased metabolic rate which may be further augmented by prematurity or illness. 2 A low Hct may therefore be insufficient to meet the metabolic oxygen requirements. (2) Anemia may decrease pulmonary vascular resistance, exacerbate left-to-right shunts, and contribute to congestive heart failure in infants with congenital heart disease? Most of a neonate's blood is replaced by the transfused blood during the standard double blood volume ET. Thus, the infant's Hct immediately following this procedure closely approximates the Hct of donor blood. The Hct of FWB may vary from 32.5 to 48.5% and will, therefore, often be too low for ET. The Hct of PRC may also vary from 55 to 80% or more, depending on the method used to prepare this component (upright sedimentation vs centrifugation vs red cell washing) and will often be too high for ET. However, PRC can be reconstituted with fresh frozen plasma to achieve a desired Hct. We have devised and tested a mathematical formula which allows blood bank technologists to reconstitute PRC with FFP to achieve a desired Hct. METHODS The pediatrician doing the ET specifies the desired Hct of the reconstituted blood. The blood bank technologist then measures the volume (weight) and Hct of the PRC, inserts these values into the following formula, and calculates the volume (weight) of FFP to add to obtain the desired Hct:" @default.
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- W1968050381 date "1982-06-01" @default.
- W1968050381 modified "2023-09-25" @default.
- W1968050381 title "The hematocrit of reconstituted blood for exchange transfusion in newborn infants" @default.
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- W1968050381 doi "https://doi.org/10.1016/s0022-3476(82)80531-3" @default.
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