FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968051399> ?p ?o ?g. }

• W1968051399 endingPage "71" @default.
• W1968051399 startingPage "59" @default.
• W1968051399 abstract "The interactions of three cationic water soluble copper(II) porphyrins, differing in peripheral substituents, with calf thymus DNA are described. Tetrakis(N-methylpyridinium-4-yl)porphinecopper(II) behaves as a simple intercalator under the conditions investigated, whereas tetrakis(4-N,N′,N″-trimethylanilinium)porphinecopper(II), binds externally, with some limited aggregation under high drug load conditions. In contrast, trans-bis(N-methylpyridinium-4-yl)diphenylporphinecopper(II) (t-CuPagg), like the free-base t-H2Pagg from which it is derived, is capable of forming extended electronically coupled arrays while bound to the DNA template. These arrays have been investigated using a combination of extinction spectroscopy, circular dichroism, RLS and resonance Raman spectroscopy. They are found to contain 105–106 porphyrin units, arranged in long, narrow organized structures. The kinetics of assembly of t-CuPagg is reported on three DNAs: ct DNA, poly(dG–dC)2 and poly(dA–dT)2. A non-conventional autocatalytic model first proposed for t-H2Pagg assembly formation is successful at fitting these data, permitting direct comparisons of kinetic parameters for the two porphyrins. It is found that the catalytic rate constant (kc) is considerably smaller for t-CuPagg than for t-H2Pagg under comparable conditions, and that the template rigidity fosters assembly formation. We also report the resonance Raman spectra of t-H2Pagg/ct DNA and t-CuPagg/ct DNA complexes. Aggregation on the DNA template changes the intensity pattern of the porphyrin's resonance Raman spectra, with some low- and high-frequency bands becoming strongly enhanced upon aggregation. We conclude that aggregation-enhanced resonance Raman spectroscopy is a useful probe of aggregation in porphyrin–DNA complexes that also gives detailed information about structural changes that accompany the aggregation process." @default.
• W1968051399 created "2016-06-24" @default.
• W1968051399 creator A5011649996 @default.
• W1968051399 creator A5017043746 @default.
• W1968051399 creator A5018957099 @default.
• W1968051399 creator A5026389106 @default.
• W1968051399 creator A5029702700 @default.
• W1968051399 creator A5036752838 @default.
• W1968051399 creator A5037954508 @default.
• W1968051399 creator A5047501836 @default.
• W1968051399 creator A5091382572 @default.
• W1968051399 date "2001-05-01" @default.
• W1968051399 modified "2023-10-16" @default.
• W1968051399 title "Interactions of copper(II) porphyrins with DNA" @default.
• W1968051399 cites W1971791608 @default.
• W1968051399 cites W1979744367 @default.
• W1968051399 cites W1983766103 @default.
• W1968051399 cites W1993183515 @default.
• W1968051399 cites W1994655426 @default.
• W1968051399 cites W1998062852 @default.
• W1968051399 cites W2002512844 @default.
• W1968051399 cites W2002870562 @default.
• W1968051399 cites W2003618878 @default.
• W1968051399 cites W2008094987 @default.
• W1968051399 cites W2009100943 @default.
• W1968051399 cites W2009512337 @default.
• W1968051399 cites W2012002884 @default.
• W1968051399 cites W2012834867 @default.
• W1968051399 cites W2013585838 @default.
• W1968051399 cites W2019310817 @default.
• W1968051399 cites W2020608366 @default.
• W1968051399 cites W2031295161 @default.
• W1968051399 cites W2032164560 @default.
• W1968051399 cites W2043384915 @default.
• W1968051399 cites W2046182336 @default.
• W1968051399 cites W2049370300 @default.
• W1968051399 cites W2052187387 @default.
• W1968051399 cites W2057025463 @default.
• W1968051399 cites W2057383918 @default.
• W1968051399 cites W2058163851 @default.
• W1968051399 cites W2058352993 @default.
• W1968051399 cites W2059885632 @default.
• W1968051399 cites W2060051279 @default.
• W1968051399 cites W2061081099 @default.
• W1968051399 cites W2065833296 @default.
• W1968051399 cites W2068519952 @default.
• W1968051399 cites W2069176389 @default.
• W1968051399 cites W2069546674 @default.
• W1968051399 cites W2070251142 @default.
• W1968051399 cites W2071416073 @default.
• W1968051399 cites W2073903901 @default.
• W1968051399 cites W2075272343 @default.
• W1968051399 cites W2076113438 @default.
• W1968051399 cites W2079194188 @default.
• W1968051399 cites W2087182711 @default.
• W1968051399 cites W2088591862 @default.
• W1968051399 cites W2089976522 @default.
• W1968051399 cites W2090467589 @default.
• W1968051399 cites W2090919322 @default.
• W1968051399 cites W2110030719 @default.
• W1968051399 cites W2130682238 @default.
• W1968051399 cites W2152924794 @default.
• W1968051399 cites W2316950343 @default.
• W1968051399 cites W2414107010 @default.
• W1968051399 cites W4251276435 @default.
• W1968051399 doi "https://doi.org/10.1016/s0020-1693(01)00340-1" @default.
• W1968051399 hasPublicationYear "2001" @default.
• W1968051399 type Work @default.
• W1968051399 sameAs 1968051399 @default.
• W1968051399 citedByCount "60" @default.
• W1968051399 countsByYear W19680513992012 @default.
• W1968051399 countsByYear W19680513992013 @default.
• W1968051399 countsByYear W19680513992014 @default.
• W1968051399 countsByYear W19680513992015 @default.
• W1968051399 countsByYear W19680513992016 @default.
• W1968051399 countsByYear W19680513992017 @default.
• W1968051399 countsByYear W19680513992018 @default.
• W1968051399 countsByYear W19680513992019 @default.
• W1968051399 countsByYear W19680513992023 @default.
• W1968051399 crossrefType "journal-article" @default.
• W1968051399 hasAuthorship W1968051399A5011649996 @default.
• W1968051399 hasAuthorship W1968051399A5017043746 @default.
• W1968051399 hasAuthorship W1968051399A5018957099 @default.
• W1968051399 hasAuthorship W1968051399A5026389106 @default.
• W1968051399 hasAuthorship W1968051399A5029702700 @default.
• W1968051399 hasAuthorship W1968051399A5036752838 @default.
• W1968051399 hasAuthorship W1968051399A5037954508 @default.
• W1968051399 hasAuthorship W1968051399A5047501836 @default.
• W1968051399 hasAuthorship W1968051399A5091382572 @default.
• W1968051399 hasConcept C109214941 @default.
• W1968051399 hasConcept C120665830 @default.
• W1968051399 hasConcept C121332964 @default.
• W1968051399 hasConcept C133571119 @default.
• W1968051399 hasConcept C137824038 @default.
• W1968051399 hasConcept C139210041 @default.
• W1968051399 hasConcept C148898269 @default.
• W1968051399 hasConcept C178790620 @default.
• W1968051399 hasConcept C179104552 @default.

• next