Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968052104> ?p ?o ?g. }
- W1968052104 endingPage "91" @default.
- W1968052104 startingPage "78" @default.
- W1968052104 abstract "Context: Prenylated caged xanthones are “privileged structure” characterized by the presence of the unusual 4-oxo-tricyclo[4.3.1.03,7]dec-8-en-2-one scaffold. The natural sources of these compounds confines mainly in the Garcinia genus in the family of Guttiferae. Gambogic acid is the most abundant substance and most of the studies have been done on this compound, particularly as a new potential antitumor agent. The history, sources, structural diversity, and biological activities of these compounds are covered.Objective: This review is written with the intention to provide additional aspects from what have been published of prenylated caged xanthones, including history, sources, structural diversity, and biological activities.Methods: This review has been compiled using information from a number of reliable references mainly from major databases including SciFinder, ScienceDirect, and PubMed.Results: More than 120 prenylated caged xanthones have been found in the plant genera Garcinia, Cratoxylum, and Dascymaschalon. These compounds exhibited various potentially useful biological activities such as anticancer, anti-HIV-1, antibacterial, anti-inflammatory, and neurotrophic activities.Conclusions: Prenylated caged xanthones, both naturally occurring and synthetic analogues, have been identified as promising bioactive compounds, especially for anticancer agents. Gambogic acid has been demonstrated to be a highly valuable lead compound for antitumor chemotherapy. The structure activity relationship (SAR) study of its analogues is still the subject of intensive research. Apoptosis cytotoxic mechanism has been identified as the major pathway. Research on the delineation of the in-depth mechanism of action is still on-going. Analogues of gambogic acid had been identified to be effective against a rare and special form of liver cancer, cholangiocarcinoma for which currently there is no chemotherapeutic treatment available." @default.
- W1968052104 created "2016-06-24" @default.
- W1968052104 creator A5026225825 @default.
- W1968052104 creator A5044286518 @default.
- W1968052104 creator A5052593016 @default.
- W1968052104 creator A5078833398 @default.
- W1968052104 creator A5088919248 @default.
- W1968052104 date "2011-12-23" @default.
- W1968052104 modified "2023-10-01" @default.
- W1968052104 title "Prenylated caged xanthones: Chemistry and biology" @default.
- W1968052104 cites W121486356 @default.
- W1968052104 cites W1964115359 @default.
- W1968052104 cites W1965754915 @default.
- W1968052104 cites W1967392725 @default.
- W1968052104 cites W1968198960 @default.
- W1968052104 cites W1971257733 @default.
- W1968052104 cites W1971746121 @default.
- W1968052104 cites W1975069567 @default.
- W1968052104 cites W1978483539 @default.
- W1968052104 cites W1979774606 @default.
- W1968052104 cites W1979955490 @default.
- W1968052104 cites W1980767434 @default.
- W1968052104 cites W1981258173 @default.
- W1968052104 cites W1990430889 @default.
- W1968052104 cites W1992410464 @default.
- W1968052104 cites W1998022986 @default.
- W1968052104 cites W1998428853 @default.
- W1968052104 cites W2000588535 @default.
- W1968052104 cites W2004779724 @default.
- W1968052104 cites W2005276660 @default.
- W1968052104 cites W2008062425 @default.
- W1968052104 cites W2009975117 @default.
- W1968052104 cites W2010809759 @default.
- W1968052104 cites W2019341167 @default.
- W1968052104 cites W2019403955 @default.
- W1968052104 cites W2020231972 @default.
- W1968052104 cites W2024368682 @default.
- W1968052104 cites W2026000514 @default.
- W1968052104 cites W2028953364 @default.
- W1968052104 cites W2031031105 @default.
- W1968052104 cites W2031232827 @default.
- W1968052104 cites W2034407136 @default.
- W1968052104 cites W2034846356 @default.
- W1968052104 cites W2035288922 @default.
- W1968052104 cites W2035980063 @default.
- W1968052104 cites W2037813798 @default.
- W1968052104 cites W2039565578 @default.
- W1968052104 cites W2041833179 @default.
- W1968052104 cites W2049308474 @default.
- W1968052104 cites W2050979959 @default.
- W1968052104 cites W2053416691 @default.
- W1968052104 cites W2054859420 @default.
- W1968052104 cites W2056376154 @default.
- W1968052104 cites W2056793355 @default.
- W1968052104 cites W2057327734 @default.
- W1968052104 cites W2057698795 @default.
- W1968052104 cites W2063632674 @default.
- W1968052104 cites W2070143816 @default.
- W1968052104 cites W2071647990 @default.
- W1968052104 cites W2074967723 @default.
- W1968052104 cites W2076582758 @default.
- W1968052104 cites W2084125722 @default.
- W1968052104 cites W2086640032 @default.
- W1968052104 cites W2088799974 @default.
- W1968052104 cites W2095522313 @default.
- W1968052104 cites W2096185813 @default.
- W1968052104 cites W2110401218 @default.
- W1968052104 cites W2113868312 @default.
- W1968052104 cites W2130583697 @default.
- W1968052104 cites W2131456594 @default.
- W1968052104 cites W2132066721 @default.
- W1968052104 cites W2133449816 @default.
- W1968052104 cites W2136339421 @default.
- W1968052104 cites W2136421867 @default.
- W1968052104 cites W2144908891 @default.
- W1968052104 cites W2147481302 @default.
- W1968052104 cites W2164224712 @default.
- W1968052104 cites W2168386853 @default.
- W1968052104 cites W2949849222 @default.
- W1968052104 cites W3021902102 @default.
- W1968052104 doi "https://doi.org/10.3109/13880209.2011.636176" @default.
- W1968052104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22196584" @default.
- W1968052104 hasPublicationYear "2011" @default.
- W1968052104 type Work @default.
- W1968052104 sameAs 1968052104 @default.
- W1968052104 citedByCount "70" @default.
- W1968052104 countsByYear W19680521042013 @default.
- W1968052104 countsByYear W19680521042014 @default.
- W1968052104 countsByYear W19680521042015 @default.
- W1968052104 countsByYear W19680521042016 @default.
- W1968052104 countsByYear W19680521042017 @default.
- W1968052104 countsByYear W19680521042018 @default.
- W1968052104 countsByYear W19680521042019 @default.
- W1968052104 countsByYear W19680521042020 @default.
- W1968052104 countsByYear W19680521042021 @default.
- W1968052104 countsByYear W19680521042022 @default.
- W1968052104 countsByYear W19680521042023 @default.
- W1968052104 crossrefType "journal-article" @default.