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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968074776> ?p ?o ?g. }

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• W1968074776 startingPage "1180" @default.
• W1968074776 abstract "Abstract: We have determined the whole promoter sequence and the transcriptional startpoint of the mouse glial fibrillary acidic protein (GFAP) gene and characterized the promoter function. We found that the cis elements for astrocyte specific expression are located within 256 bp from the transcription startpoint. We defined by DNase I footprinting assay three trans-acting factor binding sites (GFI, GFII, and GFIII) using brain or C6 astrocytoma nuclear extracts. GFI, GFII, and GFIII have AP-2, NFI, and cyclic AMP-responsive element motifs, respectively. Mutations in GFII drastically decreased the promoter activity. Base substitution in GFI and GFIII abolished the cell-specific expression, resulting in the GFAP promoter expression even in some non-GFAP-producing cells." @default.
• W1968074776 created "2016-06-24" @default.
• W1968074776 creator A5025150156 @default.
• W1968074776 creator A5035555934 @default.
• W1968074776 creator A5085639432 @default.
• W1968074776 date "1990-10-01" @default.
• W1968074776 modified "2023-09-26" @default.
• W1968074776 title "Cell-Specific Expression of the Mouse Glial Fibrillary Acidic Protein Gene: Identification of the Cis- and Trans-Acting Promoter Elements for Astrocyte-Specific Expression" @default.
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• W1968074776 doi "https://doi.org/10.1111/j.1471-4159.1990.tb03123.x" @default.
• W1968074776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2398353" @default.
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