FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968077528> ?p ?o ?g. }

• W1968077528 abstract "The first experimental evidence for the development of polarized CD4+ Th1 and Th2 responses in vivo has been obtained using the murine model of infection with Leishmania major, an intracellular parasite of macrophages in their vertebrate host. Genetically determined resistance and susceptibility to infection with this parasite have been clearly demonstrated to result from the development of polarized Th1 and Th2 responses, respectively. Using this model system, the dominant role of cytokines in the induction of polarized CD4+ responses has been validated in vivo. The requisite role of IL-4 in mediating both Th2 differentiation and susceptibility to infection in BALB/c mice has directed interest towards the search for evidence of IL-4 production early after infection and identification of its cellular source. We have been able to demonstrate a burst of IL-4 production in susceptible BALB/c mice within the first day of infection with L. major and could establish that this rapidly produced IL-4 instructed Th2 lineage commitment of subsequently activated CD4+ T cells and stabilized this commitment by downregulating IL-12 Rbeta2 chain expression, resulting in susceptibility to infection. Strikingly, this early IL-4 response to infection resulted from the cognate recognition of a single epitope in a distinctive antigen, LACK, from this complex microorganism by a restricted population of CD4+ T cells that express Vbeta4-Valpha8 T cell receptors." @default.
• W1968077528 created "2016-06-24" @default.
• W1968077528 creator A5029982606 @default.
• W1968077528 creator A5059019095 @default.
• W1968077528 creator A5076472366 @default.
• W1968077528 creator A5081451299 @default.
• W1968077528 date "1999-01-01" @default.
• W1968077528 modified "2023-09-23" @default.
• W1968077528 title "Some of the Early Events Underlying Th2. Cell Maturation and Susceptibility to Leishmania major Infection in BALB/c Mice" @default.
• W1968077528 cites W1546021870 @default.
• W1968077528 cites W1546596164 @default.
• W1968077528 cites W1565797631 @default.
• W1968077528 cites W1953014027 @default.
• W1968077528 cites W1973700190 @default.
• W1968077528 cites W1990999119 @default.
• W1968077528 cites W1993946895 @default.
• W1968077528 cites W1998187743 @default.
• W1968077528 cites W2003375160 @default.
• W1968077528 cites W2010155234 @default.
• W1968077528 cites W2019993326 @default.
• W1968077528 cites W2027139443 @default.
• W1968077528 cites W2031501484 @default.
• W1968077528 cites W2038136978 @default.
• W1968077528 cites W2044325609 @default.
• W1968077528 cites W2046954690 @default.
• W1968077528 cites W2059433996 @default.
• W1968077528 cites W2062811432 @default.
• W1968077528 cites W2067049479 @default.
• W1968077528 cites W2081973949 @default.
• W1968077528 cites W2088256755 @default.
• W1968077528 cites W2107860814 @default.
• W1968077528 cites W2116797822 @default.
• W1968077528 cites W2123789998 @default.
• W1968077528 cites W2143157380 @default.
• W1968077528 cites W2158121971 @default.
• W1968077528 cites W2168930459 @default.
• W1968077528 cites W2172466148 @default.
• W1968077528 cites W2189453901 @default.
• W1968077528 cites W4313331468 @default.
• W1968077528 cites W4313343474 @default.
• W1968077528 doi "https://doi.org/10.1515/bc.1999.112" @default.
• W1968077528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10494841" @default.
• W1968077528 hasPublicationYear "1999" @default.
• W1968077528 type Work @default.
• W1968077528 sameAs 1968077528 @default.
• W1968077528 citedByCount "6" @default.
• W1968077528 crossrefType "journal-article" @default.
• W1968077528 hasAuthorship W1968077528A5029982606 @default.
• W1968077528 hasAuthorship W1968077528A5059019095 @default.
• W1968077528 hasAuthorship W1968077528A5076472366 @default.
• W1968077528 hasAuthorship W1968077528A5081451299 @default.
• W1968077528 hasConcept C136764020 @default.
• W1968077528 hasConcept C147483822 @default.
• W1968077528 hasConcept C203014093 @default.
• W1968077528 hasConcept C207001950 @default.
• W1968077528 hasConcept C2780599195 @default.
• W1968077528 hasConcept C2781092759 @default.
• W1968077528 hasConcept C2908647359 @default.
• W1968077528 hasConcept C41008148 @default.
• W1968077528 hasConcept C54355233 @default.
• W1968077528 hasConcept C71924100 @default.
• W1968077528 hasConcept C71928629 @default.
• W1968077528 hasConcept C86803240 @default.
• W1968077528 hasConcept C8891405 @default.
• W1968077528 hasConcept C95444343 @default.
• W1968077528 hasConcept C99454951 @default.
• W1968077528 hasConceptScore W1968077528C136764020 @default.
• W1968077528 hasConceptScore W1968077528C147483822 @default.
• W1968077528 hasConceptScore W1968077528C203014093 @default.
• W1968077528 hasConceptScore W1968077528C207001950 @default.
• W1968077528 hasConceptScore W1968077528C2780599195 @default.
• W1968077528 hasConceptScore W1968077528C2781092759 @default.
• W1968077528 hasConceptScore W1968077528C2908647359 @default.
• W1968077528 hasConceptScore W1968077528C41008148 @default.
• W1968077528 hasConceptScore W1968077528C54355233 @default.
• W1968077528 hasConceptScore W1968077528C71924100 @default.
• W1968077528 hasConceptScore W1968077528C71928629 @default.
• W1968077528 hasConceptScore W1968077528C86803240 @default.
• W1968077528 hasConceptScore W1968077528C8891405 @default.
• W1968077528 hasConceptScore W1968077528C95444343 @default.
• W1968077528 hasConceptScore W1968077528C99454951 @default.
• W1968077528 hasIssue "7-8" @default.
• W1968077528 hasLocation W19680775281 @default.
• W1968077528 hasLocation W19680775282 @default.
• W1968077528 hasOpenAccess W1968077528 @default.
• W1968077528 hasPrimaryLocation W19680775281 @default.
• W1968077528 hasRelatedWork W2022368429 @default.
• W1968077528 hasRelatedWork W2057733649 @default.
• W1968077528 hasRelatedWork W2220102944 @default.
• W1968077528 hasRelatedWork W2253440606 @default.
• W1968077528 hasRelatedWork W2300372494 @default.
• W1968077528 hasRelatedWork W2409441623 @default.
• W1968077528 hasRelatedWork W2413866350 @default.
• W1968077528 hasRelatedWork W3214099642 @default.
• W1968077528 hasRelatedWork W4210976760 @default.
• W1968077528 hasRelatedWork W4320483874 @default.
• W1968077528 hasVolume "380" @default.
• W1968077528 isParatext "false" @default.
• W1968077528 isRetracted "false" @default.
• W1968077528 magId "1968077528" @default.

• next