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- W1968087101 abstract "Abstract Aim We tested the utility of topical application of Chloroquine-Solid Lipid Nanoparticle loaded gel against rheumatoid arthritis using Complete Freund's adjuvant (CFA) induced arthritic model. Methods Chloroquine loaded solid lipid nanoparticle (SLN) was prepared using probe sonication method. Briefly, the drug was solubilized into melted compritol which was further emulsified using aqueous medium followed by subjection to ultra-sonication to reduce the globule size. Further cooling the nano sized emulsion rendered SLN which was incorporated into a gel matrix. Ex vivo permeability study of the same was also performed using Franz diffusion cell, taking chloroquine phosphate gel as standard. Pharmacodynamics study (Radiographic & histopathology analysis) was performed to evaluate the efficacy of the formulation in arthritis induced rats. Results SLN with a particle size of 113.75 nm and entrapment efficiency of 97.23% were obtained. It was found from ex-vivo permeation study that chloroquine-SLN loaded gel shows maximum retention in skin as compared to chloroquine phosphate gel. Radiographic and histopathology studies of the arthritic rats treated with Chloroquine SLN gel revealed lesser extent of bone and cartilage degradation as compared to those treated with chloroquine phosphate gel. Conclusion The chloroquine-SLN loaded gel had greater protective potential over chloroquine phosphate gel. It may be possible to target the affected site locally and overcome the problems of gastrointestinal as well as dose dependent systemic side effects associated with oral administration of chloroquine." @default.
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- W1968087101 date "2015-06-01" @default.
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- W1968087101 title "Anti-rheumatic activity of chloroquine-SLN gel on wistar rats using complete freund's adjuvant (CFA) model" @default.
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- W1968087101 doi "https://doi.org/10.1016/j.injr.2015.03.008" @default.
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