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• W1968090144 startingPage "3608" @default.
• W1968090144 abstract "The pathogenesis of syphilis reflects invasive properties of Treponema pallidum, but the actual mode of tissue invasion is unknown. We have found two in vitro parallels of treponemal invasiveness. We tested whether motile T. pallidum could invade host cells by determining the fate of radiolabeled motile organisms added to a HeLa cell monolayer; 26% of treponemes associated with the monolayer in a trypsin-resistant niche, presumably between the monolayer and the surface to which it adhered, but did not attain intracellularity. Attachment of T. pallidum to cultured human and rabbit aortic and human umbilical vein endothelial cells was 2-fold greater than to HeLa cells. We added T. pallidum to aortic endothelial cells grown on membrane filters under conditions in which tight intercellular junctions had formed. T. pallidum was able to pass through the endothelial cell monolayers without altering tight junctions, as measured by electrical resistance. In contrast, heat-killed T. pallidum and the nonpathogen Treponema phagedenis biotype Reiter failed to penetrate the monolayer. Transmission electron micrographs of sections of the monolayer showed T. pallidum in intercellular junctions. Our in vitro observations suggest that these highly motile spirochetes may leave the circulation by invading the junctions between endothelial cells." @default.
• W1968090144 created "2016-06-24" @default.
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• W1968090144 date "1988-05-01" @default.
• W1968090144 modified "2023-10-02" @default.
• W1968090144 title "Treponema pallidum invades intercellular junctions of endothelial cell monolayers." @default.
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• W1968090144 doi "https://doi.org/10.1073/pnas.85.10.3608" @default.
• W1968090144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/280263" @default.
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