FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968093211> ?p ?o ?g. }

• W1968093211 endingPage "6898" @default.
• W1968093211 startingPage "6895" @default.
• W1968093211 abstract "Based on molecular docking analysis of earlier results, we designed a series of 2,5-disubstituted furans/pyrroles (5a–h) as HIV-1 entry inhibitors. Compounds were synthesized by Suzuki–Miyaura cross coupling, followed by a Knoevenagel condensation or Wittig reaction. Four of these compounds were found to be effective in inhibiting HIV-1 infection, with the best compounds being 5f and 5h, which exhibited significant inhibition on HIV-1IIIB infection at micromolar levels with low cytotoxicity. These compounds are also effective in blocking HIV-1 mediated cell-cell fusion and the gp41 six-helix bundle formation, suggesting that they are also HIV-1 fusion inhibitors targeting gp41 and have potential to be developed as a new class of anti-HIV-1 agents." @default.
• W1968093211 created "2016-06-24" @default.
• W1968093211 creator A5005564730 @default.
• W1968093211 creator A5006925420 @default.
• W1968093211 creator A5038750075 @default.
• W1968093211 creator A5038868099 @default.
• W1968093211 creator A5042155168 @default.
• W1968093211 creator A5047077004 @default.
• W1968093211 creator A5051588481 @default.
• W1968093211 creator A5069302796 @default.
• W1968093211 creator A5082158198 @default.
• W1968093211 creator A5088659394 @default.
• W1968093211 date "2011-11-01" @default.
• W1968093211 modified "2023-09-26" @default.
• W1968093211 title "Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41" @default.
• W1968093211 cites W2030648131 @default.
• W1968093211 cites W2043448829 @default.
• W1968093211 cites W2064492827 @default.
• W1968093211 cites W2072896745 @default.
• W1968093211 cites W2089018383 @default.
• W1968093211 cites W2130167865 @default.
• W1968093211 cites W2143312620 @default.
• W1968093211 cites W2322531281 @default.
• W1968093211 doi "https://doi.org/10.1016/j.bmcl.2011.08.081" @default.
• W1968093211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21978673" @default.
• W1968093211 hasPublicationYear "2011" @default.
• W1968093211 type Work @default.
• W1968093211 sameAs 1968093211 @default.
• W1968093211 citedByCount "31" @default.
• W1968093211 countsByYear W19680932112012 @default.
• W1968093211 countsByYear W19680932112013 @default.
• W1968093211 countsByYear W19680932112014 @default.
• W1968093211 countsByYear W19680932112015 @default.
• W1968093211 countsByYear W19680932112016 @default.
• W1968093211 countsByYear W19680932112017 @default.
• W1968093211 countsByYear W19680932112018 @default.
• W1968093211 countsByYear W19680932112019 @default.
• W1968093211 countsByYear W19680932112020 @default.
• W1968093211 countsByYear W19680932112021 @default.
• W1968093211 countsByYear W19680932112022 @default.
• W1968093211 countsByYear W19680932112023 @default.
• W1968093211 crossrefType "journal-article" @default.
• W1968093211 hasAuthorship W1968093211A5005564730 @default.
• W1968093211 hasAuthorship W1968093211A5006925420 @default.
• W1968093211 hasAuthorship W1968093211A5038750075 @default.
• W1968093211 hasAuthorship W1968093211A5038868099 @default.
• W1968093211 hasAuthorship W1968093211A5042155168 @default.
• W1968093211 hasAuthorship W1968093211A5047077004 @default.
• W1968093211 hasAuthorship W1968093211A5051588481 @default.
• W1968093211 hasAuthorship W1968093211A5069302796 @default.
• W1968093211 hasAuthorship W1968093211A5082158198 @default.
• W1968093211 hasAuthorship W1968093211A5088659394 @default.
• W1968093211 hasConcept C109316439 @default.
• W1968093211 hasConcept C114373084 @default.
• W1968093211 hasConcept C147483822 @default.
• W1968093211 hasConcept C159047783 @default.
• W1968093211 hasConcept C161790260 @default.
• W1968093211 hasConcept C168395250 @default.
• W1968093211 hasConcept C185592680 @default.
• W1968093211 hasConcept C195616568 @default.
• W1968093211 hasConcept C202751555 @default.
• W1968093211 hasConcept C21951064 @default.
• W1968093211 hasConcept C2776258796 @default.
• W1968093211 hasConcept C2777355660 @default.
• W1968093211 hasConcept C2778037500 @default.
• W1968093211 hasConcept C3013748606 @default.
• W1968093211 hasConcept C54355233 @default.
• W1968093211 hasConcept C55493867 @default.
• W1968093211 hasConcept C71240020 @default.
• W1968093211 hasConcept C86803240 @default.
• W1968093211 hasConceptScore W1968093211C109316439 @default.
• W1968093211 hasConceptScore W1968093211C114373084 @default.
• W1968093211 hasConceptScore W1968093211C147483822 @default.
• W1968093211 hasConceptScore W1968093211C159047783 @default.
• W1968093211 hasConceptScore W1968093211C161790260 @default.
• W1968093211 hasConceptScore W1968093211C168395250 @default.
• W1968093211 hasConceptScore W1968093211C185592680 @default.
• W1968093211 hasConceptScore W1968093211C195616568 @default.
• W1968093211 hasConceptScore W1968093211C202751555 @default.
• W1968093211 hasConceptScore W1968093211C21951064 @default.
• W1968093211 hasConceptScore W1968093211C2776258796 @default.
• W1968093211 hasConceptScore W1968093211C2777355660 @default.
• W1968093211 hasConceptScore W1968093211C2778037500 @default.
• W1968093211 hasConceptScore W1968093211C3013748606 @default.
• W1968093211 hasConceptScore W1968093211C54355233 @default.
• W1968093211 hasConceptScore W1968093211C55493867 @default.
• W1968093211 hasConceptScore W1968093211C71240020 @default.
• W1968093211 hasConceptScore W1968093211C86803240 @default.
• W1968093211 hasIssue "22" @default.
• W1968093211 hasLocation W19680932111 @default.
• W1968093211 hasLocation W19680932112 @default.
• W1968093211 hasOpenAccess W1968093211 @default.
• W1968093211 hasPrimaryLocation W19680932111 @default.
• W1968093211 hasRelatedWork W1968093211 @default.
• W1968093211 hasRelatedWork W1973220101 @default.
• W1968093211 hasRelatedWork W1992426124 @default.
• W1968093211 hasRelatedWork W2011419101 @default.
• W1968093211 hasRelatedWork W2015840684 @default.

• next