Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968095358> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1968095358 endingPage "3600" @default.
- W1968095358 startingPage "3594" @default.
- W1968095358 abstract "The clinical and prognostic significance of leukoerythroblastic anemia (LKEA) in patients with metastatic prostate cancer and, in general, patients with disseminated solid tumors is poorly understood. Therefore, the authors studied a population of patients with metastatic prostate cancer refractory to hormonal therapy to assess the incidence, clinical features, and prognostic implications of LKEA.The medical records of 106 patients with hormone-refractory prostate cancer metastatic to bone seen at the Tucson Veterans Affairs Medical Center between 1985 and 1991 were reviewed retrospectively. The clinical and laboratory data, number of packed erythrocyte transfusions required, and length of survival from the time of diagnosis of hormone-refractory disease until last follow-up visit or death were investigated in 91 identified patients.Twenty-six of 91 patients (28.6%) were found to have LKEA. LKEA developed before or at the time of diagnosis of hormone-refractory disease in 8 patients and after diagnosis of hormone-refractory disease in 18 patients. The presence of LKEA was associated with significantly lower hemoglobin levels and platelet (Plt) counts and significantly higher total bilirubin, lactic dehydrogenase (LDH), and alkaline phosphatase values (P < 0.05). Leukopenia (< 4.0 x 10(9)/l leukocytes), thrombocytopenia (< 150 x 10(9)/l Plt), elevated LDH levels (> 220 U/l), and laboratory evidence of disseminated intravascular coagulation (DIC) were more common in patients with LKEA than in those without LKEA (P < 0.01). Microangiopathic hemolysis was seen in only 2 of 91 patients (2.1%). Patients with LKEA had significantly greater transfusion requirements compared with patients without LKEA (P < 0.0001), but the median survival length was not significantly different (9 months versus 11 months, respectively). The presence of DIC and LDH levels of 500 U/l or greater in patients with LKEA was associated with a poor prognosis.LKEA is a relatively common finding in patients with hormone-refractory metastatic prostate cancer and is associated with greater transfusion requirements. Its presence, however, does not affect survival significantly." @default.
- W1968095358 created "2016-06-24" @default.
- W1968095358 creator A5057559668 @default.
- W1968095358 creator A5063793130 @default.
- W1968095358 creator A5068234093 @default.
- W1968095358 creator A5089742658 @default.
- W1968095358 date "1993-06-01" @default.
- W1968095358 modified "2023-10-17" @default.
- W1968095358 title "Leukoerythroblastic anemia in metastatic prostate cancer. Clinical and prognostic significance in patients with hormone-refractory disease" @default.
- W1968095358 cites W1980465635 @default.
- W1968095358 cites W2008901047 @default.
- W1968095358 cites W2030581818 @default.
- W1968095358 cites W2045770232 @default.
- W1968095358 cites W2072004855 @default.
- W1968095358 cites W2090295967 @default.
- W1968095358 cites W2125724868 @default.
- W1968095358 cites W2298441979 @default.
- W1968095358 cites W2333529497 @default.
- W1968095358 cites W2338213344 @default.
- W1968095358 cites W4249244482 @default.
- W1968095358 doi "https://doi.org/10.1002/1097-0142(19930601)71:11<3594::aid-cncr2820711121>3.0.co;2-o" @default.
- W1968095358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8490908" @default.
- W1968095358 hasPublicationYear "1993" @default.
- W1968095358 type Work @default.
- W1968095358 sameAs 1968095358 @default.
- W1968095358 citedByCount "19" @default.
- W1968095358 countsByYear W19680953582012 @default.
- W1968095358 countsByYear W19680953582013 @default.
- W1968095358 countsByYear W19680953582015 @default.
- W1968095358 countsByYear W19680953582017 @default.
- W1968095358 countsByYear W19680953582019 @default.
- W1968095358 countsByYear W19680953582020 @default.
- W1968095358 countsByYear W19680953582021 @default.
- W1968095358 crossrefType "journal-article" @default.
- W1968095358 hasAuthorship W1968095358A5057559668 @default.
- W1968095358 hasAuthorship W1968095358A5063793130 @default.
- W1968095358 hasAuthorship W1968095358A5068234093 @default.
- W1968095358 hasAuthorship W1968095358A5089742658 @default.
- W1968095358 hasBestOaLocation W19680953581 @default.
- W1968095358 hasConcept C121608353 @default.
- W1968095358 hasConcept C126322002 @default.
- W1968095358 hasConcept C2778248108 @default.
- W1968095358 hasConcept C2778585876 @default.
- W1968095358 hasConcept C2778734968 @default.
- W1968095358 hasConcept C2780192828 @default.
- W1968095358 hasConcept C2781127562 @default.
- W1968095358 hasConcept C2908647359 @default.
- W1968095358 hasConcept C71924100 @default.
- W1968095358 hasConcept C89560881 @default.
- W1968095358 hasConcept C90924648 @default.
- W1968095358 hasConcept C99454951 @default.
- W1968095358 hasConceptScore W1968095358C121608353 @default.
- W1968095358 hasConceptScore W1968095358C126322002 @default.
- W1968095358 hasConceptScore W1968095358C2778248108 @default.
- W1968095358 hasConceptScore W1968095358C2778585876 @default.
- W1968095358 hasConceptScore W1968095358C2778734968 @default.
- W1968095358 hasConceptScore W1968095358C2780192828 @default.
- W1968095358 hasConceptScore W1968095358C2781127562 @default.
- W1968095358 hasConceptScore W1968095358C2908647359 @default.
- W1968095358 hasConceptScore W1968095358C71924100 @default.
- W1968095358 hasConceptScore W1968095358C89560881 @default.
- W1968095358 hasConceptScore W1968095358C90924648 @default.
- W1968095358 hasConceptScore W1968095358C99454951 @default.
- W1968095358 hasIssue "11" @default.
- W1968095358 hasLocation W19680953581 @default.
- W1968095358 hasLocation W19680953582 @default.
- W1968095358 hasOpenAccess W1968095358 @default.
- W1968095358 hasPrimaryLocation W19680953581 @default.
- W1968095358 hasRelatedWork W1606527783 @default.
- W1968095358 hasRelatedWork W2056921935 @default.
- W1968095358 hasRelatedWork W2167336034 @default.
- W1968095358 hasRelatedWork W2314390669 @default.
- W1968095358 hasRelatedWork W2374911868 @default.
- W1968095358 hasRelatedWork W2409255193 @default.
- W1968095358 hasRelatedWork W2725901619 @default.
- W1968095358 hasRelatedWork W3032477347 @default.
- W1968095358 hasRelatedWork W3122877358 @default.
- W1968095358 hasRelatedWork W417577713 @default.
- W1968095358 hasVolume "71" @default.
- W1968095358 isParatext "false" @default.
- W1968095358 isRetracted "false" @default.
- W1968095358 magId "1968095358" @default.
- W1968095358 workType "article" @default.