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• W1968098076 abstract "Rate, depth, and duration of compression are the principal determinants of experimental spinal cord injury (SCI) severity. Since existing models do not allow independent control of these variables, the interaction of these factors has not been fully elucidated. The purpose of this study was to define the interactive relation of velocity (V) and compression (C) in SCI using a constrained stroke pneumatic impactor that allowed independent control of these variables. Computer simulation of previous weight-drop experiments using a lumped-mass model were compared with this series of impacts. After rigid stabilization of adjacent cervical vertebrae, the spinal cord (SC) in 48 male ferrets was compressed through the C6-C7 interspace. Maximum compression was 25%, 35%, 50%, or 65% of the SC diameter. Impacts were delivered at five velocities from 1.5 m/s to 6 m/s. Severity of injury was determined by pre and postinjury measurement of somatosensory evoked potentials (SEP) and blinded quantitation of histopathologic findings. Twenty-three of 48 animals (48%) had measurable SEP at 4 hs. No animal recovered SEP at 65% compression at any velocity, or at a velocity of 6 m/s for any level of compression. Recovery of SEP and histologic severity score correlated better with velocity-compression product, or maximum viscous response (VC) than with either V or C alone. The mean histologic severity score was higher in animals exhibiting no recovery of SEP. Modeling the viscoelastic elements of the SC using existing force-time and force-deflection data suggests that estimates of compression from current weight-drop techniques may be inaccurate. At low contact velocity, functional and anatomic damage is best predicted by maximum SC compression. However, as velocity increases, SCI severity becomes a function of the viscous response (VC), demonstrating the rate sensitivity of spinal cord tissue. Tolerance to SC compression decreases as the rate of deformation increases. This helps to explain apparent discrepancies between compression and severity of experimental SCI." @default.
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• W1968098076 date "1988-01-01" @default.
• W1968098076 modified "2023-09-23" @default.
• W1968098076 title "Interaction of Contact Velocity and Cord Compression in Determining the Severity of Spinal Cord Injury" @default.
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• W1968098076 doi "https://doi.org/10.1089/neu.1988.5.187" @default.
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