FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968113823> ?p ?o ?g. }

• W1968113823 endingPage "201" @default.
• W1968113823 startingPage "201" @default.
• W1968113823 abstract "Syndecans, a family of transmembrane heparan sulphate proteoglycans, contribute to various biological processes, including adhesion, motility, proliferation, differentiation and morphogenesis. We document here the involvement of syndecan-2 acting alone or co-operatively with integrin α5β1, for regulation of actin-cytoskeletal organization on cell adhesion to fibronectin, using fibronectin-recombinant polypeptides containing the ligands for either or both of these receptors as substrata. Lewis lung carcinoma-derived low-metastatic P29 cells binding to the substrata by both receptors formed actin stress fibres, whereas those binding by syndecan-2 or integrin α5β1 alone formed filopodia or cortex actin. In contrast, higher metastatic LM66-H11 cells formed cortex actin even on substrata containing both ligands. Northern-blot and flow-cytometric analyses revealed that syndecan-2 expression in LM66-H11 cells was significantly lower (1/4.5 in mRNA and 1/8 in cell-surface expression) than in P29 cells, whereas expression levels of integrin α5β1 and other syndecans were similar in both cell types. These results suggest that the failure of LM66-H11 to form stress fibres is due to a lower expression of syndecan-2 than that due to a threshold for its function. This was confirmed by the finding that overexpression of syndecan-2 by transfection of its cDNA into LM66-H11 cells caused the formation of stress fibres on the fibronectin substratum. These in vitro cellular responses of the two clones might reflect their in vivo situation in primary tumours in which P29 cells with a stroma-inducing capacity were immediately surrounded by fibronectin-rich matrix formed by the induced stromal cells, whereas LM66-H11 cells without such capacity were not surrounded by a similar matrix." @default.
• W1968113823 created "2016-06-24" @default.
• W1968113823 creator A5000691284 @default.
• W1968113823 creator A5010116609 @default.
• W1968113823 creator A5020148012 @default.
• W1968113823 creator A5035622513 @default.
• W1968113823 creator A5045830706 @default.
• W1968113823 creator A5047735202 @default.
• W1968113823 creator A5048199213 @default.
• W1968113823 creator A5087050239 @default.
• W1968113823 date "2002-04-15" @default.
• W1968113823 modified "2023-09-27" @default.
• W1968113823 title "The role of syndecan-2 in regulation of actin-cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones" @default.
• W1968113823 cites W142250820 @default.
• W1968113823 cites W144961662 @default.
• W1968113823 cites W1505216941 @default.
• W1968113823 cites W1579494178 @default.
• W1968113823 cites W1605153099 @default.
• W1968113823 cites W1908417742 @default.
• W1968113823 cites W1971387567 @default.
• W1968113823 cites W1972078597 @default.
• W1968113823 cites W1976213001 @default.
• W1968113823 cites W1986306825 @default.
• W1968113823 cites W1987781871 @default.
• W1968113823 cites W1991708828 @default.
• W1968113823 cites W1998715260 @default.
• W1968113823 cites W2013381560 @default.
• W1968113823 cites W2017696307 @default.
• W1968113823 cites W2022005976 @default.
• W1968113823 cites W2024422510 @default.
• W1968113823 cites W2045891730 @default.
• W1968113823 cites W2053001031 @default.
• W1968113823 cites W2056829959 @default.
• W1968113823 cites W2057021679 @default.
• W1968113823 cites W2072871114 @default.
• W1968113823 cites W2073355679 @default.
• W1968113823 cites W2079607346 @default.
• W1968113823 cites W2097509210 @default.
• W1968113823 cites W2101950619 @default.
• W1968113823 cites W2102598791 @default.
• W1968113823 cites W2105300288 @default.
• W1968113823 cites W2125344500 @default.
• W1968113823 cites W2132079001 @default.
• W1968113823 cites W2135096442 @default.
• W1968113823 cites W2139960392 @default.
• W1968113823 cites W2146897705 @default.
• W1968113823 cites W2148458479 @default.
• W1968113823 cites W2165123145 @default.
• W1968113823 cites W2168535042 @default.
• W1968113823 cites W2169829977 @default.
• W1968113823 cites W2188060873 @default.
• W1968113823 cites W2262089856 @default.
• W1968113823 cites W2287070054 @default.
• W1968113823 cites W2410633966 @default.
• W1968113823 doi "https://doi.org/10.1042/0264-6021:3630201" @default.
• W1968113823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1222468" @default.
• W1968113823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11931647" @default.
• W1968113823 hasPublicationYear "2002" @default.
• W1968113823 type Work @default.
• W1968113823 sameAs 1968113823 @default.
• W1968113823 citedByCount "32" @default.
• W1968113823 countsByYear W19681138232013 @default.
• W1968113823 countsByYear W19681138232014 @default.
• W1968113823 countsByYear W19681138232015 @default.
• W1968113823 countsByYear W19681138232017 @default.
• W1968113823 countsByYear W19681138232019 @default.
• W1968113823 countsByYear W19681138232021 @default.
• W1968113823 countsByYear W19681138232022 @default.
• W1968113823 crossrefType "journal-article" @default.
• W1968113823 hasAuthorship W1968113823A5000691284 @default.
• W1968113823 hasAuthorship W1968113823A5010116609 @default.
• W1968113823 hasAuthorship W1968113823A5020148012 @default.
• W1968113823 hasAuthorship W1968113823A5035622513 @default.
• W1968113823 hasAuthorship W1968113823A5045830706 @default.
• W1968113823 hasAuthorship W1968113823A5047735202 @default.
• W1968113823 hasAuthorship W1968113823A5048199213 @default.
• W1968113823 hasAuthorship W1968113823A5087050239 @default.
• W1968113823 hasBestOaLocation W19681138232 @default.
• W1968113823 hasConcept C125705527 @default.
• W1968113823 hasConcept C142669718 @default.
• W1968113823 hasConcept C1491633281 @default.
• W1968113823 hasConcept C151166631 @default.
• W1968113823 hasConcept C153911025 @default.
• W1968113823 hasConcept C170493617 @default.
• W1968113823 hasConcept C189165786 @default.
• W1968113823 hasConcept C195687474 @default.
• W1968113823 hasConcept C2781099445 @default.
• W1968113823 hasConcept C2993400109 @default.
• W1968113823 hasConcept C55493867 @default.
• W1968113823 hasConcept C62478195 @default.
• W1968113823 hasConcept C65001120 @default.
• W1968113823 hasConcept C85789140 @default.
• W1968113823 hasConcept C86492073 @default.
• W1968113823 hasConcept C86803240 @default.
• W1968113823 hasConcept C95444343 @default.
• W1968113823 hasConceptScore W1968113823C125705527 @default.
• W1968113823 hasConceptScore W1968113823C142669718 @default.
• W1968113823 hasConceptScore W1968113823C1491633281 @default.

• next