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- W1968125565 abstract "Among the Oji-Cree of northern Ontario, women have both a higher prevalence and an earlier onset of type 2 diabetes compared to men. We studied the relationship between HNF1A S319 and both the presence of and the age-of-onset of type 2 diabetes in women and men separately. We found that: 1) in women, there was a significant difference in the mean age-of-onset of type 2 diabetes according to HNF1A genotype; and 2) in men, there was no difference in the mean age-of-onset of type 2 diabetes according to HNF1A genotype. The findings indicate that HNF1A S319 is associated with increased susceptibility to type 2 diabetes in both men and women, but with earlier age-of-onset in women only. One factor that might account for the gender difference in the onset of HNF1A S319-associated type 2 diabetes is the greater prevalence and severity, and earlier onset of, obesity among female Oji-Cree." @default.
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- W1968125565 date "2000-08-01" @default.
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- W1968125565 title "Gender, obesity, hepatic nuclear factor-1α G319S and the age-of-onset of type 2 diabetes in Canadian Oji-Cree" @default.
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- W1968125565 doi "https://doi.org/10.1038/sj.ijo.0801258" @default.
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