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• W1968128532 abstract "Elevated cardiac markers plus one other indication of infarction (ECG recordings or imaging modalities) are the recommended criteria for the diagnosis of acute myocardial infarction. The cardiac specificity of troponin enhances its diagnostic sensitivity and specificity, thus making it the gold standard for acute myocardial infarction (AMI) in the context of patient presenting with symptoms of ischemia. The availability and analytical validation of rapid point of care test for troponin is therefore essential for optimum care of patients presenting with symptoms of ischemia. The Innotrac Aio!™ 2nd generation troponin I immunoassay is based on a time-resolved fluorometry concept. Using a universal all-in-one dry reagent concept, all the analyte specific reagents (three different mouse monoclonal antibodies) are built into a single cup. The test utilizes different monoclonal antibodies targeted against stable and unstable parts of troponin I molecule to circumvent the interference. Addition of 20 μL sample (whole blood) together with buffer initiates the reaction which is brought close to equilibrium in 15 minutes. After the wash step the Europium chelate-derived signal is measured directly from the dried surface. Total time for test is 18 minutes. Forty-one samples ethylene diamine tetraacetic acid (EDTA whole blood) were taken, among which were 19 samples with troponin I levels greater than the cut-off for AMI (0.22 μg/L). Patient samples (EDTA whole blood) with individual hematocrit (HCT) correction and with mean HCT value of 0.37 were correlated. The HCT value of each EDTA whole blood was determined by CELL-DYN® 1700 (Abbott, Santa Clara, CA). Simultaneously collected serum samples were used for the determination of troponin I on Dimension RxL (troponin I, Dade-Behring, Newark, DE). Measured HCT and 0.37 HCT correlation was: r = 0.973, P < 0.05. Passing-Bablok regression was used to quantify the agreement between the two methods. The 2nd generation troponin I assay on the Innotrac Aio!™ show a significant correlation with Dimension RxL (r = 0.996, slope 0.3794, intercept -0.0407, P < 0.05). The data presented here show that the 2nd generation troponin I on the Innotrac Aio!™ is a very good and reliable POC test. In one case, result on Dimension RxL was below (0.60 μg/L) cut-off for AMI while on Aio!™, it was above cutoff (0.22 μg/L), which demonstrates an improved sensitivity for the 2nd generation troponin I." @default.
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• W1968128532 date "2005-03-01" @default.
• W1968128532 modified "2023-09-25" @default.
• W1968128532 title "Diagnostic Importance of Point of Care Second Generation Innotrac Aio!??? Cardiac Troponin I in Acute Myocardial Infarction" @default.
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• W1968128532 doi "https://doi.org/10.1097/01.poc.0000159626.18586.f7" @default.
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