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- W1968148979 abstract "The kisspeptins are the peptide products of the KiSS-1 gene and the endogenous agonists for the GPR54 receptor. Although KiSS-1 was initially discovered as a metastasis suppressor gene, recent evidence suggests the kisspeptin/GPR54 system is a key regulator of the reproductive system. Disrupted GPR54 signalling causes hypogonadotrophic hypogonadism in rodents and man. Central or peripheral administration of kisspeptin potently stimulates the hypothalamic-pituitary-gonadal axis, increasing circulating gonadotrophin concentrations in a number of animal models. These effects appear likely to be mediated via the hypothalamic gonadotrophin-releasing hormone system, although kisspeptins may have direct effects on the anterior pituitary gland. Hypothalamic KiSS-1 expression is regulated by circulating sex steroids. The precise physiological role of the kisspeptin system in the regulation of reproductive function remains to be elucidated." @default.
- W1968148979 created "2016-06-24" @default.
- W1968148979 creator A5015218199 @default.
- W1968148979 date "2005-08-01" @default.
- W1968148979 modified "2023-09-26" @default.
- W1968148979 title "Kisspeptins: Regulators of Metastasis and the Hypothalamic-Pituitary-Gonadal Axis" @default.
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- W1968148979 doi "https://doi.org/10.1111/j.1365-2826.2005.01328.x" @default.
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