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• W1968165571 abstract "The photosensitizing ability of C 60 /2-hydroxypropyl- β -cyclodextrin (HP- β -CyD) nanoparticles under visible light irradiation was studied by electron spin resonance (ESR) and phototoxicity on cancer cells. In addition, the photoinduced antitumor effect to the tumor-bearing mice was evaluated. C 60 nanoparticles were prepared by grinding a mixture of HP- β -CyD. The resulting C 60 /HP- β -CyD nanoparticles were highly-sensitive to visible light and generated higher levels of 1 O 2 than protoporphyrin IX (PpIX). C 60 /HP- β -CyD reduced the viability of cancer cells (HeLa cells and A549 cells) in response to irradiation by visible light in a dose-dependent manner. The IC 50 values of the C 60 /HP- β -CyD nanoparticles was 10 μ M for HeLa cells and 60 μ M for A549 cells at an irradiation level of 35 mW/cm 2 . The photodynamic effect of C 60 /HP- β -CyD nanoparticles on the in vivo growth of mouse sarcoma S-180 cells was evaluated after intratumor injection. The outcome of PDT by C 60 /HP- β -CyD was directly dependent on the dose of irradiated light. Treatment with C 60 /HP- β -CyD nanoparticles at a C 60 dose of 2.0 mg/kg under visible light irradiation at 350 mW/cm 2 (63 J/cm 2 ) markedly suppressed tumor growth, whereas that at 30 J/cm 2 was less effective. These findings suggest that C 60 /HP- β -CyD nanoparticles represent a promising candidate for use in cancer treatment by PDT." @default.
• W1968165571 created "2016-06-24" @default.
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• W1968165571 date "2014-01-01" @default.
• W1968165571 modified "2023-10-02" @default.
• W1968165571 title "Potential Use of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:msub><mml:mrow><mml:mtext>C</mml:mtext></mml:mrow><mml:mrow><mml:mtext>60</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>/2-Hydroxypropyl-<i>β</i>-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer" @default.
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• W1968165571 doi "https://doi.org/10.1155/2014/570506" @default.
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