FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968171024> ?p ?o ?g. }

• W1968171024 endingPage "1055" @default.
• W1968171024 startingPage "1049" @default.
• W1968171024 abstract "ATP-binding cassette (ABC) transporters represent one of the largest families of proteins, and transport a variety of substrates ranging from ions to amphipathic anticancer drugs. The functional unit of an ABC transporter is comprised of two transmembrane domains and two cytoplasmic ABC ATPase domains. The energy of the binding and hydrolysis of ATP is used to transport the substrates across membranes. An ABC domain consists of conserved regions, the Walker A and B motifs, the signature (or C) region and the D, H and Q loops. We recently described the A-loop (Aromatic residue interacting with the Adenine ring of ATP), a highly conserved aromatic residue approximately 25 amino acids upstream of the Walker A motif that is essential for ATP-binding. Here, we review the mutational analysis of this subdomain in human P-glycoprotein as well as homology modeling, structural and data mining studies that provide evidence for a functional role of the A-loop in ATP-binding in most members of the superfamily of ABC transporters." @default.
• W1968171024 created "2016-06-24" @default.
• W1968171024 creator A5002229441 @default.
• W1968171024 creator A5081852574 @default.
• W1968171024 creator A5081938413 @default.
• W1968171024 creator A5091041425 @default.
• W1968171024 date "2005-12-22" @default.
• W1968171024 modified "2023-10-17" @default.
• W1968171024 title "The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding" @default.
• W1968171024 cites W1536266674 @default.
• W1968171024 cites W1629774220 @default.
• W1968171024 cites W1776236658 @default.
• W1968171024 cites W192621565 @default.
• W1968171024 cites W1927723646 @default.
• W1968171024 cites W1964619751 @default.
• W1968171024 cites W1967921270 @default.
• W1968171024 cites W1969008019 @default.
• W1968171024 cites W1969609100 @default.
• W1968171024 cites W1981109070 @default.
• W1968171024 cites W1987641460 @default.
• W1968171024 cites W1990043592 @default.
• W1968171024 cites W1994772523 @default.
• W1968171024 cites W2009672824 @default.
• W1968171024 cites W2013083986 @default.
• W1968171024 cites W2015451276 @default.
• W1968171024 cites W2015800304 @default.
• W1968171024 cites W2022000951 @default.
• W1968171024 cites W2026984793 @default.
• W1968171024 cites W2033432987 @default.
• W1968171024 cites W2041877620 @default.
• W1968171024 cites W2052170812 @default.
• W1968171024 cites W2055771920 @default.
• W1968171024 cites W2056523624 @default.
• W1968171024 cites W2065956146 @default.
• W1968171024 cites W2072135452 @default.
• W1968171024 cites W2081969998 @default.
• W1968171024 cites W2094303590 @default.
• W1968171024 cites W2094537302 @default.
• W1968171024 cites W2098142549 @default.
• W1968171024 cites W2136615212 @default.
• W1968171024 cites W2151875532 @default.
• W1968171024 cites W2156342386 @default.
• W1968171024 cites W2158266834 @default.
• W1968171024 cites W2161849629 @default.
• W1968171024 cites W2162097287 @default.
• W1968171024 cites W2169992673 @default.
• W1968171024 doi "https://doi.org/10.1016/j.febslet.2005.12.051" @default.
• W1968171024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16412422" @default.
• W1968171024 hasPublicationYear "2005" @default.
• W1968171024 type Work @default.
• W1968171024 sameAs 1968171024 @default.
• W1968171024 citedByCount "151" @default.
• W1968171024 countsByYear W19681710242012 @default.
• W1968171024 countsByYear W19681710242013 @default.
• W1968171024 countsByYear W19681710242014 @default.
• W1968171024 countsByYear W19681710242015 @default.
• W1968171024 countsByYear W19681710242016 @default.
• W1968171024 countsByYear W19681710242017 @default.
• W1968171024 countsByYear W19681710242018 @default.
• W1968171024 countsByYear W19681710242019 @default.
• W1968171024 countsByYear W19681710242020 @default.
• W1968171024 countsByYear W19681710242021 @default.
• W1968171024 countsByYear W19681710242022 @default.
• W1968171024 countsByYear W19681710242023 @default.
• W1968171024 crossrefType "journal-article" @default.
• W1968171024 hasAuthorship W1968171024A5002229441 @default.
• W1968171024 hasAuthorship W1968171024A5081852574 @default.
• W1968171024 hasAuthorship W1968171024A5081938413 @default.
• W1968171024 hasAuthorship W1968171024A5091041425 @default.
• W1968171024 hasBestOaLocation W19681710241 @default.
• W1968171024 hasConcept C104317684 @default.
• W1968171024 hasConcept C107824862 @default.
• W1968171024 hasConcept C113027372 @default.
• W1968171024 hasConcept C118892022 @default.
• W1968171024 hasConcept C141315368 @default.
• W1968171024 hasConcept C149011108 @default.
• W1968171024 hasConcept C167625842 @default.
• W1968171024 hasConcept C169627665 @default.
• W1968171024 hasConcept C170493617 @default.
• W1968171024 hasConcept C181199279 @default.
• W1968171024 hasConcept C185592680 @default.
• W1968171024 hasConcept C23265538 @default.
• W1968171024 hasConcept C24530287 @default.
• W1968171024 hasConcept C44312359 @default.
• W1968171024 hasConcept C515207424 @default.
• W1968171024 hasConcept C51639874 @default.
• W1968171024 hasConcept C55493867 @default.
• W1968171024 hasConcept C57581600 @default.
• W1968171024 hasConcept C75578959 @default.
• W1968171024 hasConcept C86803240 @default.
• W1968171024 hasConceptScore W1968171024C104317684 @default.
• W1968171024 hasConceptScore W1968171024C107824862 @default.
• W1968171024 hasConceptScore W1968171024C113027372 @default.
• W1968171024 hasConceptScore W1968171024C118892022 @default.
• W1968171024 hasConceptScore W1968171024C141315368 @default.
• W1968171024 hasConceptScore W1968171024C149011108 @default.
• W1968171024 hasConceptScore W1968171024C167625842 @default.
• W1968171024 hasConceptScore W1968171024C169627665 @default.

• next