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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968171423> ?p ?o ?g. }

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• W1968171423 abstract "New 3-aryl-6-(3-thienyl)pyrazolo[1,5-a]pyrimidin-7-ones (2a-j) are synthesized and evaluated in vitro on Bz/GABA(A) receptors and on recombinant benzodiazepine receptors (alpha x beta 2/3 gamma 2; x = 1-3, 5) expressed in HEK293 cells. SAR studies on the new compounds are conducted and molecular modeling is accomplished to better investigate requirements leading to subtype selectivity. Some of the synthesized compounds are tested in vivo to explore their pharmacological effect as a consequence of their high alpha 1 beta 2 gamma 2 subtype selectivity observed in vitro." @default.
• W1968171423 created "2016-06-24" @default.
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• W1968171423 date "2002-12-11" @default.
• W1968171423 modified "2023-10-09" @default.
• W1968171423 title "Synthesis and Benzodiazepine Receptor Affinity of Pyrazolo[1,5-<i>a</i>]pyrimidine Derivatives. 3. New 6-(3-Thienyl) Series as α1 Selective Ligands" @default.
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• W1968171423 doi "https://doi.org/10.1021/jm020999w" @default.
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