Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968184310> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1968184310 endingPage "973" @default.
- W1968184310 startingPage "969" @default.
- W1968184310 abstract "The myocardial contractile protein myosin light chain 1 isoform (MLC-1) is released into the circulation during myocyte necrosis and could thus be a marker of low-grade myocardial damage and of poor prognosis in patients with heart failure. Two hundred eighteen patients with stable heart failure (ejection fraction [EF] <35%) and in New York Heart Association (NYHA) class III to IV had MLC-1 measured at baseline and 1 month after being randomized to the direct vasodilator flosequinan or placebo. Patients were followed a mean of 302 +/- 142 days. The prognostic value of an increase in MLC-1 above the 98th percentile of normal controls was compared with that of conventional prognostic variables in heart failure. MLC-1 was increased in over half of patients at baseline and 1 month, and this was associated with increased age, NYHA class IV, and renal insufficiency. By Kaplan-Meier survival analysis, patients with a baseline increase in MLC-1 had a greater mortality (26%) than those without an increase (15%) (p = 0.043). A significant interaction among MLC-1, survival, and treatment was found (p = 0.043). In the placebo group, MLC-1 was associated with increased mortality (29% vs 12%, p = 0.025), whereas there was no significant difference among patients receiving flosequinan. In a multivariate logistic regression model including age, treatment, and left ventricular (LV) ejection fraction, the MLC-1 chain was most predictive of mortality (p = 0.049). Thus, circulating MLC-1 is elevated in over half of patients with stable severe heart failure, and this increase is associated with a poor prognosis. Flosequinan treatment eliminates this association, highlighting the complexity of the relation between cardiac myocyte damage, drug treatment, and mortality." @default.
- W1968184310 created "2016-06-24" @default.
- W1968184310 creator A5013050501 @default.
- W1968184310 creator A5017349008 @default.
- W1968184310 creator A5021795783 @default.
- W1968184310 creator A5032552838 @default.
- W1968184310 creator A5042766753 @default.
- W1968184310 creator A5054349218 @default.
- W1968184310 creator A5085843860 @default.
- W1968184310 date "2002-11-01" @default.
- W1968184310 modified "2023-10-12" @default.
- W1968184310 title "Relation of circulating cardiac myosin light chain 1 isoform in stable severe congestive heart failure to survival and treatment with flosequinan" @default.
- W1968184310 cites W1972125494 @default.
- W1968184310 cites W1974652620 @default.
- W1968184310 cites W1976248899 @default.
- W1968184310 cites W1984193593 @default.
- W1968184310 cites W2012220093 @default.
- W1968184310 cites W2012220607 @default.
- W1968184310 cites W2015471212 @default.
- W1968184310 cites W2028736562 @default.
- W1968184310 cites W2033380350 @default.
- W1968184310 cites W2056533558 @default.
- W1968184310 cites W2072514725 @default.
- W1968184310 cites W2079785257 @default.
- W1968184310 cites W2341478304 @default.
- W1968184310 cites W70189544 @default.
- W1968184310 doi "https://doi.org/10.1016/s0002-9149(02)02663-2" @default.
- W1968184310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12398964" @default.
- W1968184310 hasPublicationYear "2002" @default.
- W1968184310 type Work @default.
- W1968184310 sameAs 1968184310 @default.
- W1968184310 citedByCount "32" @default.
- W1968184310 countsByYear W19681843102012 @default.
- W1968184310 countsByYear W19681843102013 @default.
- W1968184310 countsByYear W19681843102017 @default.
- W1968184310 countsByYear W19681843102020 @default.
- W1968184310 countsByYear W19681843102021 @default.
- W1968184310 countsByYear W19681843102022 @default.
- W1968184310 crossrefType "journal-article" @default.
- W1968184310 hasAuthorship W1968184310A5013050501 @default.
- W1968184310 hasAuthorship W1968184310A5017349008 @default.
- W1968184310 hasAuthorship W1968184310A5021795783 @default.
- W1968184310 hasAuthorship W1968184310A5032552838 @default.
- W1968184310 hasAuthorship W1968184310A5042766753 @default.
- W1968184310 hasAuthorship W1968184310A5054349218 @default.
- W1968184310 hasAuthorship W1968184310A5085843860 @default.
- W1968184310 hasConcept C10515644 @default.
- W1968184310 hasConcept C126322002 @default.
- W1968184310 hasConcept C142724271 @default.
- W1968184310 hasConcept C164705383 @default.
- W1968184310 hasConcept C204787440 @default.
- W1968184310 hasConcept C27081682 @default.
- W1968184310 hasConcept C2778198053 @default.
- W1968184310 hasConcept C50382708 @default.
- W1968184310 hasConcept C71924100 @default.
- W1968184310 hasConcept C78085059 @default.
- W1968184310 hasConceptScore W1968184310C10515644 @default.
- W1968184310 hasConceptScore W1968184310C126322002 @default.
- W1968184310 hasConceptScore W1968184310C142724271 @default.
- W1968184310 hasConceptScore W1968184310C164705383 @default.
- W1968184310 hasConceptScore W1968184310C204787440 @default.
- W1968184310 hasConceptScore W1968184310C27081682 @default.
- W1968184310 hasConceptScore W1968184310C2778198053 @default.
- W1968184310 hasConceptScore W1968184310C50382708 @default.
- W1968184310 hasConceptScore W1968184310C71924100 @default.
- W1968184310 hasConceptScore W1968184310C78085059 @default.
- W1968184310 hasIssue "9" @default.
- W1968184310 hasLocation W19681843101 @default.
- W1968184310 hasLocation W19681843102 @default.
- W1968184310 hasOpenAccess W1968184310 @default.
- W1968184310 hasPrimaryLocation W19681843101 @default.
- W1968184310 hasRelatedWork W1971710084 @default.
- W1968184310 hasRelatedWork W2010631330 @default.
- W1968184310 hasRelatedWork W2028196543 @default.
- W1968184310 hasRelatedWork W2072108749 @default.
- W1968184310 hasRelatedWork W2481234813 @default.
- W1968184310 hasRelatedWork W2581226876 @default.
- W1968184310 hasRelatedWork W2891746874 @default.
- W1968184310 hasRelatedWork W2920829402 @default.
- W1968184310 hasRelatedWork W3164268473 @default.
- W1968184310 hasRelatedWork W4207030337 @default.
- W1968184310 hasVolume "90" @default.
- W1968184310 isParatext "false" @default.
- W1968184310 isRetracted "false" @default.
- W1968184310 magId "1968184310" @default.
- W1968184310 workType "article" @default.