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- W1968190337 endingPage "259" @default.
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- W1968190337 abstract "Work published over the past 10–15 years has caused the neuroscience community to engage in a process of constant re-evaluation of the roles of glial cells in the mammalian central nervous system. Recent emerging evidence suggests that, in addition to carrying out various homeostatic functions within the CNS, astrocytes can also engage in a two-way dialogue with neurons. Astrocytes possess many of the receptors, and some of the ion channels, present in neurons endowing them with an ability to sense and respond to an array of neuronal signals. In addition, an expanding number of small molecules and proteins have been shown to be released by astrocytes in both health and disease. In this commentary we will highlight advances in our understanding of G protein-coupled receptor signalling in astrocytes, with a particular emphasis on metabotropic glutamate (mGlu) receptors. Discussion will focus on the major mGlu receptors expressed in astrocytes, mGlu3 and mGlu5, how these receptors can influence different aspects of astrocyte physiology, and how signalling by these G protein-coupled receptors might change under pathophysiological circumstances." @default.
- W1968190337 created "2016-06-24" @default.
- W1968190337 creator A5044018474 @default.
- W1968190337 creator A5084866615 @default.
- W1968190337 date "2012-08-01" @default.
- W1968190337 modified "2023-10-16" @default.
- W1968190337 title "G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors" @default.
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