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• W1968193928 startingPage "285" @default.
• W1968193928 abstract "The constitutive androstane receptor (CAR, NR1I3) has emerged as an important regulator of drug metabolism. CAR responds to a wide spectrum of xenobiotics by inducing expression of cytochrome P450 (CYP) enzymes and a number of other proteins responsible for drug metabolism in the liver. The xenosensor function of CAR overlaps with that of the pregnane X receptor (PXR), another xenobiotic receptor that belongs to the nuclear hormone superfamily. We observed that injection of dexamethasone (Dex), a ligand for the glucocorticoid receptor (GR) and PXR but not CAR, results in an unexpected twofold increase in the stomach weight of CAR-null animals relative to wild-type animals. Here, we show that CAR knockout mice have elevated levels of Dex in the brain, resulting in a more rapid and robust increase in the hypothalamic expression of the GR-responsive target genes encoding neuropeptide Y (NPY) and neuropeptide Y receptor subtype 1 (NPY-R1). As expected, this is accompanied by a higher increase in the food intake of the CAR-null animals. The data described here highlight the complexity of the overlapping functions of CAR and PXR." @default.
• W1968193928 created "2016-06-24" @default.
• W1968193928 creator A5062018855 @default.
• W1968193928 creator A5065801998 @default.
• W1968193928 creator A5086674835 @default.
• W1968193928 date "2004-06-01" @default.
• W1968193928 modified "2023-10-14" @default.
• W1968193928 title "Alterations in the distribution and orexigenic effects of dexamethasone in CAR-null mice" @default.
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• W1968193928 doi "https://doi.org/10.1016/j.pbb.2004.04.001" @default.
• W1968193928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15219769" @default.
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