FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968202297> ?p ?o ?g. }

• W1968202297 endingPage "3979" @default.
• W1968202297 startingPage "3968" @default.
• W1968202297 abstract "The yeast aminoacyl-tRNA synthetase (aaRS) complex is formed by the methionyl- and glutamyl-tRNA synthetases (MetRS and GluRS, respectively) and the tRNA aminoacylation cofactor Arc1p. It is considered an evolutionary intermediate between prokaryotic aaRS and the multi- aaRS complex found in higher eukaryotes. While a wealth of structural information is available on the enzymatic domains of single aaRS, insight into complex formation between eukaryotic aaRS and associated protein cofactors is missing. Here we report crystal structures of the binary complexes between the interacting domains of Arc1p and MetRS as well as those of Arc1p and GluRS at resolutions of 2.2 and 2.05 Å, respectively. The data provide a complete structural model for ternary complex formation between the interacting domains of MetRS, GluRS and Arc1p. The structures reveal that all three domains adopt a glutathione S-transferase (GST)-like fold and that simultaneous interaction of Arc1p with GluRS and MetRS is mediated by the use of a novel interface in addition to a classical GST dimerization interaction. The results demonstrate a novel role for this fold as a heteromerization domain specific to eukaryotic aaRS, associated proteins and protein translation elongation factors." @default.
• W1968202297 created "2016-06-24" @default.
• W1968202297 creator A5041911427 @default.
• W1968202297 creator A5051705273 @default.
• W1968202297 creator A5063867946 @default.
• W1968202297 creator A5086150959 @default.
• W1968202297 creator A5087759502 @default.
• W1968202297 creator A5089590993 @default.
• W1968202297 date "2006-08-12" @default.
• W1968202297 modified "2023-09-24" @default.
• W1968202297 title "Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes" @default.
• W1968202297 cites W1490306625 @default.
• W1968202297 cites W1508885706 @default.
• W1968202297 cites W1711342713 @default.
• W1968202297 cites W174069803 @default.
• W1968202297 cites W1819124197 @default.
• W1968202297 cites W1967912925 @default.
• W1968202297 cites W1973121921 @default.
• W1968202297 cites W1973634405 @default.
• W1968202297 cites W1980956149 @default.
• W1968202297 cites W1993119469 @default.
• W1968202297 cites W1997648346 @default.
• W1968202297 cites W2000840258 @default.
• W1968202297 cites W2001641653 @default.
• W1968202297 cites W2005637337 @default.
• W1968202297 cites W2005914057 @default.
• W1968202297 cites W2011017551 @default.
• W1968202297 cites W2014463993 @default.
• W1968202297 cites W2015473376 @default.
• W1968202297 cites W2018756788 @default.
• W1968202297 cites W2022058405 @default.
• W1968202297 cites W2027247170 @default.
• W1968202297 cites W2029836094 @default.
• W1968202297 cites W2031637933 @default.
• W1968202297 cites W2031772330 @default.
• W1968202297 cites W2038840577 @default.
• W1968202297 cites W2041096296 @default.
• W1968202297 cites W2049859307 @default.
• W1968202297 cites W2066668488 @default.
• W1968202297 cites W2066699299 @default.
• W1968202297 cites W2084619201 @default.
• W1968202297 cites W2085173782 @default.
• W1968202297 cites W2089683534 @default.
• W1968202297 cites W2095724872 @default.
• W1968202297 cites W2097493124 @default.
• W1968202297 cites W2097767833 @default.
• W1968202297 cites W2097789452 @default.
• W1968202297 cites W2106882534 @default.
• W1968202297 cites W2111126181 @default.
• W1968202297 cites W2130281493 @default.
• W1968202297 cites W2135372051 @default.
• W1968202297 cites W2135632270 @default.
• W1968202297 cites W2137946890 @default.
• W1968202297 cites W2139728602 @default.
• W1968202297 cites W2141885858 @default.
• W1968202297 cites W2143694829 @default.
• W1968202297 cites W2144081223 @default.
• W1968202297 cites W2155479906 @default.
• W1968202297 cites W4210400672 @default.
• W1968202297 doi "https://doi.org/10.1093/nar/gkl560" @default.
• W1968202297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1557820" @default.
• W1968202297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16914447" @default.
• W1968202297 hasPublicationYear "2006" @default.
• W1968202297 type Work @default.
• W1968202297 sameAs 1968202297 @default.
• W1968202297 citedByCount "57" @default.
• W1968202297 countsByYear W19682022972012 @default.
• W1968202297 countsByYear W19682022972013 @default.
• W1968202297 countsByYear W19682022972014 @default.
• W1968202297 countsByYear W19682022972015 @default.
• W1968202297 countsByYear W19682022972016 @default.
• W1968202297 countsByYear W19682022972017 @default.
• W1968202297 countsByYear W19682022972018 @default.
• W1968202297 countsByYear W19682022972019 @default.
• W1968202297 countsByYear W19682022972020 @default.
• W1968202297 countsByYear W19682022972021 @default.
• W1968202297 countsByYear W19682022972022 @default.
• W1968202297 countsByYear W19682022972023 @default.
• W1968202297 crossrefType "journal-article" @default.
• W1968202297 hasAuthorship W1968202297A5041911427 @default.
• W1968202297 hasAuthorship W1968202297A5051705273 @default.
• W1968202297 hasAuthorship W1968202297A5063867946 @default.
• W1968202297 hasAuthorship W1968202297A5086150959 @default.
• W1968202297 hasAuthorship W1968202297A5087759502 @default.
• W1968202297 hasAuthorship W1968202297A5089590993 @default.
• W1968202297 hasBestOaLocation W19682022971 @default.
• W1968202297 hasConcept C104317684 @default.
• W1968202297 hasConcept C105580179 @default.
• W1968202297 hasConcept C139124968 @default.
• W1968202297 hasConcept C149364088 @default.
• W1968202297 hasConcept C151238385 @default.
• W1968202297 hasConcept C153957851 @default.
• W1968202297 hasConcept C181199279 @default.
• W1968202297 hasConcept C197957613 @default.
• W1968202297 hasConcept C2779222958 @default.
• W1968202297 hasConcept C2779315393 @default.
• W1968202297 hasConcept C2910418148 @default.
• W1968202297 hasConcept C55493867 @default.

• next