Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968210984> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1968210984 endingPage "580" @default.
- W1968210984 startingPage "577" @default.
- W1968210984 abstract "Nine children with severe falciparum malaria were treated with an intravenous quinine regimen which did not require burettes or infusion pumps, to determine its practicability and to ensure that therapeutic drug concentrations were achieved and maintained throughout the dose interval. The regimen comprised quinine dihydrochloride (15 mg/kg; 12·5 mg/kg of the free base), which was added to a bag of intravenous fluid (after wastage of all but 100 mL), and given via standard giving sets over 2 h. Blood was drawn sequentially during the infusion, and for 12 h thereafter; plasma water was obtained by ultrafiltration of samples at the bedside, and quinine concentration was measured, in plasma and plasma water, by high performance liquid chromatography. Drug administration was practicable without burettes or infusion pumps; unbound drug concentrations exceeded the 99% inhibitory concentration for local parasites within 0·5 h, and remained within the therapeutic range for the entire dose interval. This loading dose regimen can now be recommended for young children in African hospitals; maintenance doses of 10 mg/kg should be given at 12 h intervals until oral antimalarial drugs are possible. These recommendations will need to be modified if susceptibility to quinine declines." @default.
- W1968210984 created "2016-06-24" @default.
- W1968210984 creator A5018692963 @default.
- W1968210984 creator A5022372798 @default.
- W1968210984 creator A5049726472 @default.
- W1968210984 creator A5053416884 @default.
- W1968210984 creator A5072332085 @default.
- W1968210984 creator A5079659950 @default.
- W1968210984 date "1994-09-01" @default.
- W1968210984 modified "2023-10-10" @default.
- W1968210984 title "Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: unbound quinine concentrations following a simple loading dose regimen" @default.
- W1968210984 cites W1818269711 @default.
- W1968210984 cites W1901110847 @default.
- W1968210984 cites W1963693714 @default.
- W1968210984 cites W1965250537 @default.
- W1968210984 cites W1986656730 @default.
- W1968210984 cites W1996421552 @default.
- W1968210984 cites W2007801262 @default.
- W1968210984 cites W2009243738 @default.
- W1968210984 cites W2021371898 @default.
- W1968210984 cites W2039193172 @default.
- W1968210984 cites W2059974010 @default.
- W1968210984 cites W2105552468 @default.
- W1968210984 cites W2411241726 @default.
- W1968210984 cites W4245177871 @default.
- W1968210984 doi "https://doi.org/10.1016/0035-9203(94)90170-8" @default.
- W1968210984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7992345" @default.
- W1968210984 hasPublicationYear "1994" @default.
- W1968210984 type Work @default.
- W1968210984 sameAs 1968210984 @default.
- W1968210984 citedByCount "28" @default.
- W1968210984 countsByYear W19682109842014 @default.
- W1968210984 countsByYear W19682109842016 @default.
- W1968210984 countsByYear W19682109842022 @default.
- W1968210984 crossrefType "journal-article" @default.
- W1968210984 hasAuthorship W1968210984A5018692963 @default.
- W1968210984 hasAuthorship W1968210984A5022372798 @default.
- W1968210984 hasAuthorship W1968210984A5049726472 @default.
- W1968210984 hasAuthorship W1968210984A5053416884 @default.
- W1968210984 hasAuthorship W1968210984A5072332085 @default.
- W1968210984 hasAuthorship W1968210984A5079659950 @default.
- W1968210984 hasConcept C112705442 @default.
- W1968210984 hasConcept C141071460 @default.
- W1968210984 hasConcept C19831878 @default.
- W1968210984 hasConcept C203014093 @default.
- W1968210984 hasConcept C2777617192 @default.
- W1968210984 hasConcept C2778048844 @default.
- W1968210984 hasConcept C2778371730 @default.
- W1968210984 hasConcept C2780035454 @default.
- W1968210984 hasConcept C2781413609 @default.
- W1968210984 hasConcept C2908793570 @default.
- W1968210984 hasConcept C42219234 @default.
- W1968210984 hasConcept C71924100 @default.
- W1968210984 hasConcept C98274493 @default.
- W1968210984 hasConceptScore W1968210984C112705442 @default.
- W1968210984 hasConceptScore W1968210984C141071460 @default.
- W1968210984 hasConceptScore W1968210984C19831878 @default.
- W1968210984 hasConceptScore W1968210984C203014093 @default.
- W1968210984 hasConceptScore W1968210984C2777617192 @default.
- W1968210984 hasConceptScore W1968210984C2778048844 @default.
- W1968210984 hasConceptScore W1968210984C2778371730 @default.
- W1968210984 hasConceptScore W1968210984C2780035454 @default.
- W1968210984 hasConceptScore W1968210984C2781413609 @default.
- W1968210984 hasConceptScore W1968210984C2908793570 @default.
- W1968210984 hasConceptScore W1968210984C42219234 @default.
- W1968210984 hasConceptScore W1968210984C71924100 @default.
- W1968210984 hasConceptScore W1968210984C98274493 @default.
- W1968210984 hasIssue "5" @default.
- W1968210984 hasLocation W19682109841 @default.
- W1968210984 hasLocation W19682109842 @default.
- W1968210984 hasOpenAccess W1968210984 @default.
- W1968210984 hasPrimaryLocation W19682109841 @default.
- W1968210984 hasRelatedWork W1967446598 @default.
- W1968210984 hasRelatedWork W2045767541 @default.
- W1968210984 hasRelatedWork W2115261803 @default.
- W1968210984 hasRelatedWork W2129015658 @default.
- W1968210984 hasRelatedWork W2408345149 @default.
- W1968210984 hasRelatedWork W2409312553 @default.
- W1968210984 hasRelatedWork W2411241726 @default.
- W1968210984 hasRelatedWork W2422956653 @default.
- W1968210984 hasRelatedWork W2436912489 @default.
- W1968210984 hasRelatedWork W2443559567 @default.
- W1968210984 hasVolume "88" @default.
- W1968210984 isParatext "false" @default.
- W1968210984 isRetracted "false" @default.
- W1968210984 magId "1968210984" @default.
- W1968210984 workType "article" @default.