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• W1968224530 abstract "1 The effects of nicotine antagonists on single twitches, trains of four twitches and tetanic contractions of the isolated diaphragm of the rat were examined. 2 Different drugs were found to produce different amounts of tetanic fade relative to depression of twitch tension. 3 The order of activity from most able, to least able to produce fade was: hexamethonium> trimetaphan = atracurium = tubocurarine>pancuronium>erabutoxin b. 4 The effect of erabutoxin b was distinctive for its almost complete lack of tetanic fade. 5 3,4-Diaminopyridine increased tetanic fade produced by tubocurarine, atracurium and hexamethonium, but not that produced by erabutoxin b. 6 It is concluded that nicotinic antagonists act at more than one site at the neuromuscular junction. Assuming block of the postjunctional acetylcholine receptor produces tension depression, a second or third site must be involved in producing tetanic fade. 7 The possibility that tetanic fade results from block of the ion channel associated with the postjunctional acetycholine receptor or from the block of a prejunctional nicotinic receptor is discussed." @default.
• W1968224530 created "2016-06-24" @default.
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• W1968224530 date "1986-11-01" @default.
• W1968224530 modified "2023-09-23" @default.
• W1968224530 title "Nicotinic antagonists produce differing amounts of tetanic fade in the isolated diaphragm of the rat" @default.
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• W1968224530 doi "https://doi.org/10.1111/j.1476-5381.1986.tb11164.x" @default.
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