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- W1968224744 abstract "Addition of dibutyryl adenosine 3<i>’</i>:5<i>’</i>-monophosphate (dcbAMP), colchicine or dbcAMP/colchicine to bone organ cultures markedly inhibited bone resorption. Calvaria of newborn mice labeled with <sup>45</sup>Ca 3 days before sacrifice were removed and cultured in medium containing <sup>3</sup>H-glucosamine. Both agents alone and in combination inhibited <sup>45</sup>Ca release. DEAE-cellulose chromatography of the papain-digested medium and bone resolved the <sup>3</sup>H-glucosamine-labeled macromolecular material into four peaks. A marked increase in radioactivity was observed in the hyaluronate fraction (peak III) of the chromatographed bone samples. The results indicate that dbcAMP does not mimic the effect of parathyroid hormone on bone resorption, but that it is similar to colchicine in both the inhibition of bone resorption and the increased incorporation of <sup>3</sup>H-glucosamine into hyaluronate. Although the role of hyaluronate, if any, in this experimental system remain elusive, the increased radioactivity associated with the hyaluronate fraction may be due to decreased degradation resulting from decreased hyaluronidase synthesis." @default.
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- W1968224744 date "1983-01-01" @default.
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- W1968224744 title "Inhibition of Bone Resorption and Increased Incorporation of <sup>3</sup>H-Glucosamine into Hyaluronate in Bone Organ Cultures Treated with Dibutyryl Cyclic AMP and Colchicine" @default.
- W1968224744 doi "https://doi.org/10.1159/000163176" @default.
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