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• W1968229404 abstract "IntroductionThe knowledge of professionals generally has a half-time ofabout 5 years. So half of everything you will read in thisreview will be outdated 5 years from now. That may be notso bad, but it also means that everything you have learnedmore than 5 years ago is only half true, and do you knowwhich half? Keeping up with the literature is an almostimpossible task and never complete. With the introductionof the new WHO classification at the EAHP/SH workshopin Bordeaux last year, several major changes are introducedinto our daily work. This will be the subject of review inthe next issue of the Journal of Hematopathology. For now,there is also quite some interesting data to digest:Biology of lymphomaHodgkin lymphomaThe successful meeting of the EAHP in Bordeaux focusedon tumor microenvironment, an exiting but difficult area.We know how important the stroma and its cells are fortumor growth, but the complexity of the interplays betweencells, reporter molecules, and matrix is so large that wehave only limited understanding. We may have to awaitfurther large steps in systems biology to get a grasp of thisby modeling. Nevertheless, interesting work is done inespecially Hodgkin lymphoma (HL), a tumor in which theenvironment is remarkably large. Chetaille et al. [1] studied63 cases of classical HL(cHL) by microarray and found thatEBV-positive cases differed in profile from EBV-negativecases by the presence of a Th1 response gene signature.Furthermore, they found that when an overexpression ofgenes related to B cells and apoptosis were present, patientshad a favorable outcome. They were able to confirm this byimmunohistochemistry: poorer prognosis in the case ofhigh percentage of either TIA-1-positive reactive cells ortopoisomerase-2-positive tumor cells, whereas high numb-ers of BCL11A, FOXP3, or CD20-positive reactive cellshad a favorable influence. Immunodetection of BCL11A, amarker of both B cells and plasmacytoid dendritic cells, hadthe strongest predictive value. EBV-positive cHL (n=108)was also studied by Asano et al. [2], and in comparisonwith age-related EBV-positive B-cell proliferations (n=34),since also the latter often has an inflammatory backgroundsimilar to cHL. cHL had a lower ratio of geographicalnecrosis, lower number of cytotoxic T cells, and a betterprognosis. Many more of such studies will be neededbefore there will be a reliable marker set that predicts whoof the relatively few patients with cHL will relapse.B-cell lymphomasAlso in B-cell lymphomas, the microenvironment is subjectof a study: de Jong et al. [3] studied with immunohisto-chemistry 61 pretreatment biopsies from patients treated ina clinical trial and found that the prognostic impact wasdifferent for the two treatment arms. CD69 expression ontumor cells was a poor prognostic sign, and an interfollic-ular infiltrate of FoxP3-positive T cells was a goodprognostic sign irrespective of the treatment arm, and theauthors suggest that a dense infiltrate of FoxP3-positive Tcells, dense and interfollicular infiltrate of CD68-positive" @default.
• W1968229404 created "2016-06-24" @default.
• W1968229404 creator A5034547037 @default.
• W1968229404 date "2009-01-01" @default.
• W1968229404 modified "2023-09-26" @default.
• W1968229404 title "New developments in the pathology of malignant lymphoma: a review of the literature published from August" @default.
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