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- W1968239699 endingPage "52" @default.
- W1968239699 startingPage "33" @default.
- W1968239699 abstract "The thyrotropin receptor (TSHR) is a G-protein-coupled receptor with a large ectodomain. TSH, acting via TSHR, regulates thyroid growth and thyroid hormone production and secretion. The TSHR undergoes complex post-translational processing involving dimerization, intramolecular cleavage, and shedding of its ectodomain, and each of these processes may influence the antigenicity of the TSHR. The TSHR is also the major autoantigen in Graves' disease, as well as a leading candidate autoantigen in both Graves' ophthalmopathy and pretibial myxedema. The naturally conformed TSHR is most effectively presented as an autoantigen to the immune system, causing the production of stimulating TSHR-Abs. There are also autoantibodies which block the TSHR from TSH action, and neutral TSHR-Abs which have no influence on TSH action. TSHR-Abs can be detected by competition assays of TSHR-Abs for labeled TSH, or monoclonal TSHR-Ab binding to solubilized TSHRs, or by bioassays using thyroid cells or mammalian cells expressing recombinant TSHRs." @default.
- W1968239699 created "2016-06-24" @default.
- W1968239699 creator A5012050273 @default.
- W1968239699 creator A5049201390 @default.
- W1968239699 creator A5066773921 @default.
- W1968239699 date "2005-03-01" @default.
- W1968239699 modified "2023-10-17" @default.
- W1968239699 title "Thyrotropin receptor antibodies: new insights into their actions and clinical relevance" @default.
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