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- W1968255194 abstract "Interactions among the insecticides DDT, methoxychlor, and dieldrin were studied in terms of their residues stored in rats' adipose tissue. A commercial rat diet was treated with the three compounds using three dose levels of each (DDT: 0, 5, 50 ppm; methoxychlor: 0, 50, 500 ppm; dieldrin: 0, 1, 10 ppm) in a factorial arrangement that permitted preparation of all 27 possible compound and dose level combinations. Female rats were fed the treated diets for 10 weeks and then sacrificed. Adipose tissue was analyzed for lipid content and residual insecticide concentrations. As reported in a previous paper, dieldrin storage was markedly reduced when DDT was present in the treatment combination. Further statistical analysis of the data has indicated a significant influence of dieldrin treatment on storage of DDT. DDT storage, when fed at the 50 ppm level, was increased by the high dieldrin treatment. Methoxychlor storage was not affected by the other treatments; however, methoxychlor caused a small, but significant, reduction in dieldrin storage. The DDE:DDT storage ratio in tissue was not influenced by either dieldrin or methoxychlor. The DDT effect is postulated to result from enhanced dieldrin metabolism by liver microsomal enzymes." @default.
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- W1968255194 date "1966-05-01" @default.
- W1968255194 modified "2023-09-23" @default.
- W1968255194 title "Insecticide interactions affecting residue accumulation in animal tissues" @default.
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- W1968255194 doi "https://doi.org/10.1016/0041-008x(66)90060-3" @default.
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