FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968263631> ?p ?o ?g. }

• W1968263631 endingPage "33" @default.
• W1968263631 startingPage "25" @default.
• W1968263631 abstract "Gene silencing using small interfering RNA (siRNA) is a promising therapeutic strategy for the treatment of various diseases, in particular, cancer. Recently, our group reported on a novel gene carrier, the micelle-like nanoparticle (MNP), based on the combination of a covalent conjugate of phospholipid and polyethylenimine (PLPEI) with polyethylene glycol (PEG) and lipids. These long-circulating MNPs loaded with plasmid DNA-mediated gene expression in distal tumors after systemic administration in vivo. In the current study, we investigated the potential of MNPs for siRNA delivery. MNPs were prepared by condensing siRNA with PLPEI at a nitrogen/phosphate ratio of 10, where the binding of siRNA is complete. The addition of a PEG/lipid coating to the PLPEI complexes generated particles with sizes of ca. 200 nm and a neutral surface charge compared with positively charged PLPEI polyplexes without the additional coating. MNPs protected the loaded siRNA against enzymatic digestion and enhanced the cellular uptake of the siRNA payload. MNPs carrying green fluorescent protein (GFP)-targeted siRNA effectively downregulated the gene in cells that stably express GFP. Finally, MNPs were non-toxic at a wide range of concentrations and for different cell lines." @default.
• W1968263631 created "2016-06-24" @default.
• W1968263631 creator A5014576744 @default.
• W1968263631 creator A5034153270 @default.
• W1968263631 creator A5038150974 @default.
• W1968263631 creator A5074966571 @default.
• W1968263631 creator A5084391530 @default.
• W1968263631 date "2010-12-29" @default.
• W1968263631 modified "2023-09-23" @default.
• W1968263631 title "Phospholipid–polyethylenimine conjugate-based micelle-like nanoparticles for siRNA delivery" @default.
• W1968263631 cites W1511669342 @default.
• W1968263631 cites W1964146045 @default.
• W1968263631 cites W1973350289 @default.
• W1968263631 cites W1975930645 @default.
• W1968263631 cites W1980560815 @default.
• W1968263631 cites W1982195500 @default.
• W1968263631 cites W1984739176 @default.
• W1968263631 cites W1998004849 @default.
• W1968263631 cites W2000888033 @default.
• W1968263631 cites W2004812096 @default.
• W1968263631 cites W2010655741 @default.
• W1968263631 cites W2017307273 @default.
• W1968263631 cites W2021043619 @default.
• W1968263631 cites W2021082805 @default.
• W1968263631 cites W2051047648 @default.
• W1968263631 cites W2054547436 @default.
• W1968263631 cites W2057491067 @default.
• W1968263631 cites W2075206227 @default.
• W1968263631 cites W2078377919 @default.
• W1968263631 cites W2079127527 @default.
• W1968263631 cites W2080071319 @default.
• W1968263631 cites W2080356693 @default.
• W1968263631 cites W2082111987 @default.
• W1968263631 cites W2085287701 @default.
• W1968263631 cites W2091211551 @default.
• W1968263631 cites W2092049057 @default.
• W1968263631 cites W2104050632 @default.
• W1968263631 cites W2153038484 @default.
• W1968263631 cites W91990295 @default.
• W1968263631 doi "https://doi.org/10.1007/s13346-010-0004-0" @default.
• W1968263631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3423223" @default.
• W1968263631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22916337" @default.
• W1968263631 hasPublicationYear "2010" @default.
• W1968263631 type Work @default.
• W1968263631 sameAs 1968263631 @default.
• W1968263631 citedByCount "35" @default.
• W1968263631 countsByYear W19682636312012 @default.
• W1968263631 countsByYear W19682636312013 @default.
• W1968263631 countsByYear W19682636312014 @default.
• W1968263631 countsByYear W19682636312015 @default.
• W1968263631 countsByYear W19682636312016 @default.
• W1968263631 countsByYear W19682636312017 @default.
• W1968263631 countsByYear W19682636312019 @default.
• W1968263631 countsByYear W19682636312020 @default.
• W1968263631 countsByYear W19682636312021 @default.
• W1968263631 countsByYear W19682636312022 @default.
• W1968263631 countsByYear W19682636312023 @default.
• W1968263631 crossrefType "journal-article" @default.
• W1968263631 hasAuthorship W1968263631A5014576744 @default.
• W1968263631 hasAuthorship W1968263631A5034153270 @default.
• W1968263631 hasAuthorship W1968263631A5038150974 @default.
• W1968263631 hasAuthorship W1968263631A5074966571 @default.
• W1968263631 hasAuthorship W1968263631A5084391530 @default.
• W1968263631 hasBestOaLocation W19682636312 @default.
• W1968263631 hasConcept C10138342 @default.
• W1968263631 hasConcept C104317684 @default.
• W1968263631 hasConcept C11268172 @default.
• W1968263631 hasConcept C119056186 @default.
• W1968263631 hasConcept C12554922 @default.
• W1968263631 hasConcept C134306372 @default.
• W1968263631 hasConcept C135983454 @default.
• W1968263631 hasConcept C153911025 @default.
• W1968263631 hasConcept C162324750 @default.
• W1968263631 hasConcept C178790620 @default.
• W1968263631 hasConcept C18150654 @default.
• W1968263631 hasConcept C184651966 @default.
• W1968263631 hasConcept C185592680 @default.
• W1968263631 hasConcept C197336794 @default.
• W1968263631 hasConcept C22615655 @default.
• W1968263631 hasConcept C2775925850 @default.
• W1968263631 hasConcept C2776964284 @default.
• W1968263631 hasConcept C2779820397 @default.
• W1968263631 hasConcept C33923547 @default.
• W1968263631 hasConcept C40767141 @default.
• W1968263631 hasConcept C49923114 @default.
• W1968263631 hasConcept C54009773 @default.
• W1968263631 hasConcept C54400483 @default.
• W1968263631 hasConcept C55493867 @default.
• W1968263631 hasConcept C86803240 @default.
• W1968263631 hasConcept C92087593 @default.
• W1968263631 hasConceptScore W1968263631C10138342 @default.
• W1968263631 hasConceptScore W1968263631C104317684 @default.
• W1968263631 hasConceptScore W1968263631C11268172 @default.
• W1968263631 hasConceptScore W1968263631C119056186 @default.
• W1968263631 hasConceptScore W1968263631C12554922 @default.
• W1968263631 hasConceptScore W1968263631C134306372 @default.
• W1968263631 hasConceptScore W1968263631C135983454 @default.
• W1968263631 hasConceptScore W1968263631C153911025 @default.

• next