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- W1968276207 abstract "Importance of the field: Comprehensive studies indicate that oltipraz exerts cancer chemopreventive effects. Oltipraz has other therapeutic potentials, which include anti-fibrotic effect, inhibition of insulin resistance, mitochondrial protection and cytoprotective effect against oxidative stress. Although antioxidant mechanisms may account for its cancer chemopreventive effect, details on the molecular mechanism still remain to be clarified.Areas covered in this review: Two major metabolic pathways of oltipraz include oxidative desulfuration of the thione to yield 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiol-3-one and molecular rearrangement to 7-methyl-6,8-bis(methylthio)H-pyrrolo[1,2-a]pyrazine. In addition to the diverse pharmacological effects of oltipraz, the oxidized metabolites may have distinct biological effects on cell survival. The AMP-activated protein kinase pathway has been recognized as a key cascade for mitochondrial protection and cell survival events, which can be activated by the oxidized metabolites of oltipraz.What the reader will gain: In this review, the metabolic activation of oltipraz and the role of the cell signaling pathways in regulating the expression of Phase II genes and antioxidant activity are discussed with particular reference to their effects on mitochondrial protection and cell survival.Take home message: In terms of therapeutic potential, the findings reviewed here demonstrate a therapeutic potential for oxidized metabolite of oltipraz and offer comparison of antioxidant capacity between metabolites and parent compound." @default.
- W1968276207 created "2016-06-24" @default.
- W1968276207 creator A5014945543 @default.
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- W1968276207 creator A5088885277 @default.
- W1968276207 creator A5089461702 @default.
- W1968276207 date "2010-01-22" @default.
- W1968276207 modified "2023-09-27" @default.
- W1968276207 title "Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz" @default.
- W1968276207 cites W1254008793 @default.
- W1968276207 cites W1489283017 @default.
- W1968276207 cites W1526007548 @default.
- W1968276207 cites W1527449265 @default.
- W1968276207 cites W1546267534 @default.
- W1968276207 cites W1573475822 @default.
- W1968276207 cites W1767614014 @default.
- W1968276207 cites W1786380341 @default.
- W1968276207 cites W1909302202 @default.
- W1968276207 cites W1965490406 @default.
- W1968276207 cites W1967323214 @default.
- W1968276207 cites W1971608015 @default.
- W1968276207 cites W1971731428 @default.
- W1968276207 cites W1972299255 @default.
- W1968276207 cites W1972635603 @default.
- W1968276207 cites W1973016992 @default.
- W1968276207 cites W1973995316 @default.
- W1968276207 cites W1976929342 @default.
- W1968276207 cites W1977501799 @default.
- W1968276207 cites W1977914031 @default.
- W1968276207 cites W1980920377 @default.
- W1968276207 cites W1980969730 @default.
- W1968276207 cites W1983602021 @default.
- W1968276207 cites W1984428820 @default.
- W1968276207 cites W1988380852 @default.
- W1968276207 cites W1988848089 @default.
- W1968276207 cites W1990223276 @default.
- W1968276207 cites W1990278643 @default.
- W1968276207 cites W1990598806 @default.
- W1968276207 cites W1994442108 @default.
- W1968276207 cites W1995633773 @default.
- W1968276207 cites W1997832379 @default.
- W1968276207 cites W1998128080 @default.
- W1968276207 cites W2005568856 @default.
- W1968276207 cites W2007078899 @default.
- W1968276207 cites W2007294454 @default.
- W1968276207 cites W2012584340 @default.
- W1968276207 cites W2012768706 @default.
- W1968276207 cites W2013065884 @default.
- W1968276207 cites W2013092934 @default.
- W1968276207 cites W2014070226 @default.
- W1968276207 cites W2015501861 @default.
- W1968276207 cites W2017784962 @default.
- W1968276207 cites W2019079031 @default.
- W1968276207 cites W2019219491 @default.
- W1968276207 cites W2022322175 @default.
- W1968276207 cites W2024289938 @default.
- W1968276207 cites W2029735473 @default.
- W1968276207 cites W2030636484 @default.
- W1968276207 cites W2032515060 @default.
- W1968276207 cites W2035884940 @default.
- W1968276207 cites W2040155866 @default.
- W1968276207 cites W2045815767 @default.
- W1968276207 cites W2046683936 @default.
- W1968276207 cites W2050512725 @default.
- W1968276207 cites W2050994990 @default.
- W1968276207 cites W2053022803 @default.
- W1968276207 cites W2054820743 @default.
- W1968276207 cites W2056137479 @default.
- W1968276207 cites W2057257618 @default.
- W1968276207 cites W2061242359 @default.
- W1968276207 cites W2061757494 @default.
- W1968276207 cites W2062203284 @default.
- W1968276207 cites W2063158149 @default.
- W1968276207 cites W2063265653 @default.
- W1968276207 cites W2066309898 @default.
- W1968276207 cites W2067450342 @default.
- W1968276207 cites W2067979493 @default.
- W1968276207 cites W2068342714 @default.
- W1968276207 cites W2071801517 @default.
- W1968276207 cites W2074800090 @default.
- W1968276207 cites W2076610743 @default.
- W1968276207 cites W2080091995 @default.
- W1968276207 cites W2081731224 @default.
- W1968276207 cites W2081988313 @default.
- W1968276207 cites W2083782923 @default.
- W1968276207 cites W2084644507 @default.
- W1968276207 cites W2092730539 @default.
- W1968276207 cites W2096361448 @default.
- W1968276207 cites W2101540167 @default.
- W1968276207 cites W2101720048 @default.
- W1968276207 cites W2104841304 @default.
- W1968276207 cites W2107101475 @default.
- W1968276207 cites W2110029891 @default.
- W1968276207 cites W2112286580 @default.
- W1968276207 cites W2113054810 @default.
- W1968276207 cites W2113710155 @default.
- W1968276207 cites W2114443210 @default.
- W1968276207 cites W2119367809 @default.