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- W1968277777 abstract "ABSTRACT This article describes an interim safety analysis of an ongoing 2-year, double-blind study to compare two doses of estrogen-androgen therapy (0.625 or 1.25 mg esterified estrogens combined with 1.25 mg or 2.5 mg methyltestosterone, respectively) with two doses of conjugated estrogens (0.625 mg or 1.25 mg conjugated equine estrogens) in 291 surgically menopausal women. Except for an excess of nausea in the estrogen-only group, reported adverse events (headache, breast pain, weight increase, vaginitis, and hirsutism) did not differ significantly between groups. The majority of adverse events were manifest by 6 months and were not dose related. Only four estrogen-androgen and two conjugated estrogen participants reported hirsutism as an adverse event, but Ferriman-Gallwey evaluations at 12 months detected increased hair growth in 14%–22% of women in each treatment group, with a slight but nonsignificant increment in the higher dose estrogen-androgen group. No significant differences between groups f..." @default.
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- W1968277777 date "1996-12-01" @default.
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- W1968277777 title "Interim Safety Analysis of a Two-Year Study Comparing Oral Estrogen-Androgen and Conjugated Estrogens in Surgically Menopausal Women" @default.
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- W1968277777 doi "https://doi.org/10.1089/jwh.1996.5.593" @default.
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