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- W1968277908 abstract "The nucleus accumbens of the rat plays a critical role in behavioral activation and appetitive motivation. Within the nucleus accumbens, the shell subarea may be especially relevant, since this site is anatomically related to other brain areas that are considered to play a critical role in the processing of motivation. We investigated the behavioral effects of local drug treatments aimed at the shell of the nucleus accumbens and tested the indirect dopamine agonist d-amphetamine, the opiate agonist morphine, and the neurokinin substance P. These substances are known to exert positive reinforcing effects, and can affect behavioral activity; effects that are physiologically closely related to the nucleus accumbens and its inputs and outputs. Our results show that unilateral microinjections of amphetamine (1.0 μg, 10.0 μg) into the shell of the nucleus accumbens dose-dependently stimulated behavioral activity (locomotion, rears, sniffing), and led to conditioned place preference. Furthermore, the effect of amphetamine on place preference was negatively related to the psychomotor stimulant action on rears. Morphine injections (5.0 μg) also stimulated behavioral activity and elicited contraversive turning, but were ineffective with respect to place preference. Finally, the neuropeptide substance P, injected in a dose range of 0.1–10.0 ng, had no significant behavioral effects. These findings are discussed with respect to the role of dopaminergic, peptidergic and cholinergic mechanisms in the nucleus accumbens. It is suggested that dopamine, opiates, and neurokinins in the shell of the nucleus accumbens are differentially involved in mediating behavioral activity and appetitive motivation." @default.
- W1968277908 created "2016-06-24" @default.
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- W1968277908 date "1998-04-01" @default.
- W1968277908 modified "2023-09-27" @default.
- W1968277908 title "Intraaccumbens injections of substance P, morphine and amphetamine: effects on conditioned place preference and behavioral activity" @default.
- W1968277908 cites W1635864650 @default.
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- W1968277908 cites W1963634631 @default.
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- W1968277908 cites W1964213807 @default.
- W1968277908 cites W1965918309 @default.
- W1968277908 cites W1968143328 @default.
- W1968277908 cites W1970486261 @default.
- W1968277908 cites W1970820877 @default.
- W1968277908 cites W1972281490 @default.
- W1968277908 cites W1973348899 @default.
- W1968277908 cites W1977526257 @default.
- W1968277908 cites W1978328770 @default.
- W1968277908 cites W1979755286 @default.
- W1968277908 cites W1981841185 @default.
- W1968277908 cites W1982641194 @default.
- W1968277908 cites W1982836473 @default.
- W1968277908 cites W1985122887 @default.
- W1968277908 cites W1987976668 @default.
- W1968277908 cites W1992396098 @default.
- W1968277908 cites W1993420915 @default.
- W1968277908 cites W2003345023 @default.
- W1968277908 cites W2004205242 @default.
- W1968277908 cites W2007277628 @default.
- W1968277908 cites W2007942266 @default.
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- W1968277908 cites W2009262293 @default.
- W1968277908 cites W2010066281 @default.
- W1968277908 cites W2010569958 @default.
- W1968277908 cites W2013677380 @default.
- W1968277908 cites W2013851440 @default.
- W1968277908 cites W2014415095 @default.
- W1968277908 cites W2016115175 @default.
- W1968277908 cites W2020648244 @default.
- W1968277908 cites W2021469534 @default.
- W1968277908 cites W2021540475 @default.
- W1968277908 cites W2023221544 @default.
- W1968277908 cites W2025421654 @default.
- W1968277908 cites W2026812180 @default.
- W1968277908 cites W2026913847 @default.
- W1968277908 cites W2027274005 @default.
- W1968277908 cites W2031000254 @default.
- W1968277908 cites W2036165827 @default.
- W1968277908 cites W2037090188 @default.
- W1968277908 cites W2043130405 @default.
- W1968277908 cites W2047687410 @default.
- W1968277908 cites W2048844674 @default.
- W1968277908 cites W2048941040 @default.
- W1968277908 cites W2049427752 @default.
- W1968277908 cites W2053625565 @default.
- W1968277908 cites W2054044560 @default.
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- W1968277908 cites W2054913936 @default.
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- W1968277908 cites W2067496786 @default.
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- W1968277908 cites W2078115460 @default.
- W1968277908 cites W2078429352 @default.
- W1968277908 cites W2079555920 @default.
- W1968277908 cites W2079872791 @default.
- W1968277908 cites W2082556611 @default.
- W1968277908 cites W2085032279 @default.
- W1968277908 cites W2090487851 @default.
- W1968277908 cites W2111360128 @default.
- W1968277908 cites W2122592499 @default.
- W1968277908 cites W2129636663 @default.
- W1968277908 cites W2133672910 @default.
- W1968277908 cites W2136003148 @default.
- W1968277908 cites W2143481865 @default.
- W1968277908 cites W2156782574 @default.
- W1968277908 cites W2158776928 @default.
- W1968277908 cites W2169940170 @default.
- W1968277908 cites W2172113265 @default.
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- W1968277908 doi "https://doi.org/10.1016/s0006-8993(98)00062-6" @default.
- W1968277908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9593886" @default.
- W1968277908 hasPublicationYear "1998" @default.
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