FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968284239> ?p ?o ?g. }

• W1968284239 abstract "Calciotropic hormones as well as biochemical parameters of bone formation and resorption show circadian rhythms. In a previous study in the rat, we observed a circadian rhythm in serum bone-resorbing activity (SBRA). In the present study, we investigated whether there was a circadian rhythm of SBRA in human serum. For this purpose, we studied 10 healthy premenopausal women and 5 healthy men. Blood was collected every 2 h, and urine samples were collected during 4-h periods for 24 h. For the determination of SBRA, media were prepared by reconstituting serum samples with Dulbecco's Modified Eagle's Medium at a ratio of 20% serum and 80% Dulbecco's Modified Eagle's Medium. Limb bones were dissected from 19-day old fetal rats prelabelled with 45Ca and were cultured for 72 h in the presence of the sera. Bone resorption was assessed from the 45Ca released into the culture medium and from that retained in the bone and was expressed as percentage 45Ca release. Serum calcium, phosphorus, PTH, cortisol, and urinary pyridinium cross-links were also determined. SBRA in human serum followed a circadian rhythm with a peak at about 0300 h and a nadir at 0700 h. There was no significant difference between the rhythm of SBRA of women and men. At concurrent time points, SBRA and serum PTH were positively correlated (r = 0.629; P < 0.01), and SBRA and serum cortisol were negatively correlated (r = 0.797; P < 0.01). To further investigate the possible contribution of these hormones to SBRA, either neutralizing anti-PTH antibody or RU-486 (mifepristone), a glucocorticoid receptor antagonist, was added to the serum samples of 6 subjects. Neutralizing the effect of PTH did not change the pattern of SBRA rhythm. The addition of RU-486 had a significant effect on the rhythm of SBRA, reducing the peak and nadir amplitudes. Thus we conclude that cortisol plays a major role in the rhythm of SBRA present in human serum; however, the influence of other factors cannot be excluded. Cortisol may be an important determinant of the circadian rhythm of bone resorption in vivo." @default.
• W1968284239 created "2016-06-24" @default.
• W1968284239 creator A5023016452 @default.
• W1968284239 creator A5047981948 @default.
• W1968284239 creator A5049886691 @default.
• W1968284239 creator A5057928016 @default.
• W1968284239 creator A5064307236 @default.
• W1968284239 creator A5074644944 @default.
• W1968284239 date "1995-11-01" @default.
• W1968284239 modified "2023-10-18" @default.
• W1968284239 title "Circadian rhythm of in vitro bone-resorbing activity in human serum." @default.
• W1968284239 cites W1970446508 @default.
• W1968284239 cites W1981791036 @default.
• W1968284239 cites W1992639196 @default.
• W1968284239 cites W2022911715 @default.
• W1968284239 cites W2049286230 @default.
• W1968284239 cites W2062355922 @default.
• W1968284239 cites W2075594458 @default.
• W1968284239 cites W2086636882 @default.
• W1968284239 cites W2117105307 @default.
• W1968284239 cites W2134199290 @default.
• W1968284239 cites W2140458754 @default.
• W1968284239 cites W2145954404 @default.
• W1968284239 cites W2185294482 @default.
• W1968284239 cites W2204331034 @default.
• W1968284239 cites W2278818314 @default.
• W1968284239 cites W2413526997 @default.
• W1968284239 cites W2440747115 @default.
• W1968284239 cites W2776961186 @default.
• W1968284239 cites W32757302 @default.
• W1968284239 doi "https://doi.org/10.1210/jcem.80.11.7593424" @default.
• W1968284239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7593424" @default.
• W1968284239 hasPublicationYear "1995" @default.
• W1968284239 type Work @default.
• W1968284239 sameAs 1968284239 @default.
• W1968284239 citedByCount "17" @default.
• W1968284239 countsByYear W19682842392013 @default.
• W1968284239 countsByYear W19682842392016 @default.
• W1968284239 countsByYear W19682842392018 @default.
• W1968284239 countsByYear W19682842392021 @default.
• W1968284239 countsByYear W19682842392023 @default.
• W1968284239 crossrefType "journal-article" @default.
• W1968284239 hasAuthorship W1968284239A5023016452 @default.
• W1968284239 hasAuthorship W1968284239A5047981948 @default.
• W1968284239 hasAuthorship W1968284239A5049886691 @default.
• W1968284239 hasAuthorship W1968284239A5057928016 @default.
• W1968284239 hasAuthorship W1968284239A5064307236 @default.
• W1968284239 hasAuthorship W1968284239A5074644944 @default.
• W1968284239 hasConcept C121446783 @default.
• W1968284239 hasConcept C126322002 @default.
• W1968284239 hasConcept C134018914 @default.
• W1968284239 hasConcept C146562846 @default.
• W1968284239 hasConcept C185592680 @default.
• W1968284239 hasConcept C519063684 @default.
• W1968284239 hasConcept C673006 @default.
• W1968284239 hasConcept C71315377 @default.
• W1968284239 hasConcept C71924100 @default.
• W1968284239 hasConcept C86803240 @default.
• W1968284239 hasConceptScore W1968284239C121446783 @default.
• W1968284239 hasConceptScore W1968284239C126322002 @default.
• W1968284239 hasConceptScore W1968284239C134018914 @default.
• W1968284239 hasConceptScore W1968284239C146562846 @default.
• W1968284239 hasConceptScore W1968284239C185592680 @default.
• W1968284239 hasConceptScore W1968284239C519063684 @default.
• W1968284239 hasConceptScore W1968284239C673006 @default.
• W1968284239 hasConceptScore W1968284239C71315377 @default.
• W1968284239 hasConceptScore W1968284239C71924100 @default.
• W1968284239 hasConceptScore W1968284239C86803240 @default.
• W1968284239 hasLocation W19682842391 @default.
• W1968284239 hasLocation W19682842392 @default.
• W1968284239 hasOpenAccess W1968284239 @default.
• W1968284239 hasPrimaryLocation W19682842391 @default.
• W1968284239 hasRelatedWork W1902125591 @default.
• W1968284239 hasRelatedWork W1968284239 @default.
• W1968284239 hasRelatedWork W1990422519 @default.
• W1968284239 hasRelatedWork W1995262052 @default.
• W1968284239 hasRelatedWork W2088946921 @default.
• W1968284239 hasRelatedWork W2105609354 @default.
• W1968284239 hasRelatedWork W2115981624 @default.
• W1968284239 hasRelatedWork W2121975880 @default.
• W1968284239 hasRelatedWork W2171117474 @default.
• W1968284239 hasRelatedWork W4250103921 @default.
• W1968284239 isParatext "false" @default.
• W1968284239 isRetracted "false" @default.
• W1968284239 magId "1968284239" @default.
• W1968284239 workType "article" @default.