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• W1968297316 endingPage "955" @default.
• W1968297316 startingPage "947" @default.
• W1968297316 abstract "Synovitis in rheumatoid arthritis is characterized by infiltration of the synovium by T and B lymphocytes and monocytes, as well as by the proliferation of synovial lining cells, fibroblasts, and endothelial cells. To study synovial cell-T cell interactions in vitro, we established cultures of fibroblast-like synovial cells, and used these cells in a synovial cell-T cell binding assay. Using T cells at various stages of differentiation and activation, we found that human thymocytes and mitogen-activated peripheral blood T cells bound to fibroblast-like synovial cells, whereas fresh peripheral blood T cells did not. Moreover, activated T cells from inflammatory synovial tissue or from synovial fluid also bound to fibroblast-like synovial cells cultured in vivo. Antibodies against certain epitopes of the T cell CD2 (35.1) and synovial cell lymphocyte function-associated antigen-3 (LFA-3) (TS2/9) molecules inhibited synovial cell-thymocyte binding. However, these same anti-CD2 and anti-LFA-3 antibodies only partially inhibited synovial cell binding to activated normal peripheral blood T cells. Moreover, T cells from inflammatory synovium from rheumatoid arthritis and psoriatic arthritis patients also bound to synovial cells in vitro. These findings demonstrate that fibroblast-like synovial cells are capable of binding to human T cells in vitro, and suggest that during the course of inflammatory synovitis, synovial fibroblast-T cell interactions may occur in vivo." @default.
• W1968297316 created "2016-06-24" @default.
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• W1968297316 date "1988-08-01" @default.
• W1968297316 modified "2023-09-27" @default.
• W1968297316 title "Synovial microenvironment-t cell interactions" @default.
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• W1968297316 doi "https://doi.org/10.1002/art.1780310802" @default.
• W1968297316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2457376" @default.
• W1968297316 hasPublicationYear "1988" @default.
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