Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968299778> ?p ?o ?g. }
- W1968299778 endingPage "1564" @default.
- W1968299778 startingPage "1557" @default.
- W1968299778 abstract "The N-methyl-D-aspartate receptor (NMDAR) coagonists glycine, D-serine and L-proline play crucial roles in NMDAR-dependent neurotransmission and are associated with a range of neuropsychiatric disorders. We conducted the first genome-wide association study of concentrations of these coagonists and their enantiomers in plasma and cerebrospinal fluid (CSF) of human subjects from the general population (N=414). Genetic variants at chromosome 22q11.2, located in and near PRODH (proline dehydrogenase), were associated with L-proline in plasma (β=0.29; P=6.38 × 10(-10)). The missense variant rs17279437 in the proline transporter SLC6A20 was associated with L-proline in CSF (β=0.28; P=9.68 × 10(-9)). Suggestive evidence of association was found for the D-serine plasma-CSF ratio at the D-amino-acid oxidase (DAO) gene (β=-0.28; P=9.08 × 10(-8)), whereas a variant in SRR (that encodes serine racemase and is associated with schizophrenia) constituted the most strongly associated locus for the L-serine to D-serine ratio in CSF. All these genes are highly expressed in rodent meninges and choroid plexus, anatomical regions relevant to CSF physiology. The enzymes and transporters they encode may be targeted to further construe the nature of NMDAR coagonist involvement in NMDAR gating. Furthermore, the highlighted genetic variants may be followed up in clinical populations, for example, schizophrenia and 22q11 deletion syndrome. Overall, this targeted metabolomics approach furthers the understanding of NMDAR coagonist concentration variability and sets the stage for non-targeted CSF metabolomics projects." @default.
- W1968299778 created "2016-06-24" @default.
- W1968299778 creator A5004995142 @default.
- W1968299778 creator A5009368988 @default.
- W1968299778 creator A5020398622 @default.
- W1968299778 creator A5021526460 @default.
- W1968299778 creator A5022719663 @default.
- W1968299778 creator A5022855713 @default.
- W1968299778 creator A5026769077 @default.
- W1968299778 creator A5028536247 @default.
- W1968299778 creator A5031613969 @default.
- W1968299778 creator A5033983868 @default.
- W1968299778 creator A5035750579 @default.
- W1968299778 creator A5036323969 @default.
- W1968299778 creator A5037777651 @default.
- W1968299778 creator A5049244051 @default.
- W1968299778 creator A5056125935 @default.
- W1968299778 creator A5056129137 @default.
- W1968299778 creator A5059115008 @default.
- W1968299778 creator A5060460490 @default.
- W1968299778 creator A5061187532 @default.
- W1968299778 creator A5078375751 @default.
- W1968299778 creator A5081871874 @default.
- W1968299778 creator A5084532266 @default.
- W1968299778 date "2015-02-10" @default.
- W1968299778 modified "2023-10-16" @default.
- W1968299778 title "Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma" @default.
- W1968299778 cites W1967611229 @default.
- W1968299778 cites W1971964419 @default.
- W1968299778 cites W1980187532 @default.
- W1968299778 cites W1982270474 @default.
- W1968299778 cites W1982819316 @default.
- W1968299778 cites W1984996211 @default.
- W1968299778 cites W1985901090 @default.
- W1968299778 cites W1989568128 @default.
- W1968299778 cites W1993015366 @default.
- W1968299778 cites W1994573823 @default.
- W1968299778 cites W1994967480 @default.
- W1968299778 cites W2004044531 @default.
- W1968299778 cites W2008162817 @default.
- W1968299778 cites W2008565079 @default.
- W1968299778 cites W2010158663 @default.
- W1968299778 cites W2017771330 @default.
- W1968299778 cites W2017826413 @default.
- W1968299778 cites W2022180773 @default.
- W1968299778 cites W2028445187 @default.
- W1968299778 cites W2031404611 @default.
- W1968299778 cites W2031635484 @default.
- W1968299778 cites W2036796078 @default.
- W1968299778 cites W2038335379 @default.
- W1968299778 cites W2039872800 @default.
- W1968299778 cites W2043830156 @default.
- W1968299778 cites W2045883616 @default.
- W1968299778 cites W2046106956 @default.
- W1968299778 cites W2048181000 @default.
- W1968299778 cites W2052127850 @default.
- W1968299778 cites W2067446209 @default.
- W1968299778 cites W2068898125 @default.
- W1968299778 cites W2071586792 @default.
- W1968299778 cites W2074112976 @default.
- W1968299778 cites W2074369357 @default.
- W1968299778 cites W2075289811 @default.
- W1968299778 cites W2075698740 @default.
- W1968299778 cites W2078790185 @default.
- W1968299778 cites W2081628874 @default.
- W1968299778 cites W2082720266 @default.
- W1968299778 cites W2084712270 @default.
- W1968299778 cites W2091982759 @default.
- W1968299778 cites W2095305985 @default.
- W1968299778 cites W2101357408 @default.
- W1968299778 cites W2103092890 @default.
- W1968299778 cites W2109909801 @default.
- W1968299778 cites W2111307685 @default.
- W1968299778 cites W2111528698 @default.
- W1968299778 cites W2121357459 @default.
- W1968299778 cites W2122282311 @default.
- W1968299778 cites W2126867710 @default.
- W1968299778 cites W2134204196 @default.
- W1968299778 cites W2138345444 @default.
- W1968299778 cites W2145566795 @default.
- W1968299778 cites W2161140570 @default.
- W1968299778 cites W2161633633 @default.
- W1968299778 cites W2162836113 @default.
- W1968299778 cites W2164339823 @default.
- W1968299778 cites W2166501262 @default.
- W1968299778 cites W2166711199 @default.
- W1968299778 cites W2169718193 @default.
- W1968299778 cites W2338087157 @default.
- W1968299778 cites W2339740702 @default.
- W1968299778 cites W4230685253 @default.
- W1968299778 doi "https://doi.org/10.1038/mp.2014.190" @default.
- W1968299778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25666758" @default.
- W1968299778 hasPublicationYear "2015" @default.
- W1968299778 type Work @default.
- W1968299778 sameAs 1968299778 @default.
- W1968299778 citedByCount "16" @default.
- W1968299778 countsByYear W19682997782015 @default.
- W1968299778 countsByYear W19682997782016 @default.