FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968304503> ?p ?o ?g. }

• W1968304503 endingPage "41" @default.
• W1968304503 startingPage "32" @default.
• W1968304503 abstract "Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Whereas insulin resistance and obesity are considered major risk factors for the development and progression of NAFLD, the genetic underpinnings are unclear. Before 2008, candidate gene studies based on prior knowledge of pathophysiology of fatty liver yielded conflicting results. In 2008, Romeo et al. published the first genome wide association study and reported the strongest genetic signal for the presence of fatty liver (PNPLA3, patatin-like phospholipase domain containing 3; rs738409). Since then, two additional genome wide scans were published and identified 9 additional genetic variants. Whereas these results shed light into the understanding of the genetics of NAFLD, most of associations have not been replicated in independent samples and, therefore, remain undetermined the significance of these findings. This review aims to summarize the understanding of genetic epidemiology of NAFLD and highlights the gaps in knowledge. La enfermedad hepática no alcohólica (EHNA) es la enfermedad crónica del hígado más común en el mundo. Si bien se considera que la resistencia a la insulina y la obesidad son factores de riesgo importantes para el desarrollo y progresión de la misma, sus bases genéticas no están claras. Antes de 2008, los estudios sobre genes candidatos basados en conocimientos previos de la fisiopatología de la esteatosis hepática produjeron resultados contradictorios. En 2008, Romeo et al. publicaron el primer estudio de asociación amplia del genoma que presentaba indicios genéticos sólidos de la presencia de esteatosis hepática (PNPLA3, dominio de la fosfolipasa-patatina 3; rs738409). Desde entonces, se han publicado dos estudios adicionales de asociación amplia del genoma en los que se identificaron otras nueve variantes genéticas. Si bien estos resultados arrojan luz sobre la genética de la EHNA, la mayoría de las asociaciones no se han replicado en muestras independientes y, por tanto, la importancia de estos hallazgos continúa siendo incierta. Esta revisión pretende resumir los conocimientos actuales sobre la epidemiología genética de la EHNA y destaca las áreas de incertidumbre." @default.
• W1968304503 created "2016-06-24" @default.
• W1968304503 creator A5030970274 @default.
• W1968304503 date "2012-01-01" @default.
• W1968304503 modified "2023-10-01" @default.
• W1968304503 title "Genetic factors associated with the presence and progression of nonalcoholic fatty liver disease: A narrative review" @default.
• W1968304503 cites W129116767 @default.
• W1968304503 cites W1510002896 @default.
• W1968304503 cites W1963543568 @default.
• W1968304503 cites W1965512299 @default.
• W1968304503 cites W1968354167 @default.
• W1968304503 cites W1972820017 @default.
• W1968304503 cites W1973060382 @default.
• W1968304503 cites W1973978057 @default.
• W1968304503 cites W1974436444 @default.
• W1968304503 cites W1981561595 @default.
• W1968304503 cites W1982426530 @default.
• W1968304503 cites W1983381584 @default.
• W1968304503 cites W1985592156 @default.
• W1968304503 cites W1987192397 @default.
• W1968304503 cites W1987312373 @default.
• W1968304503 cites W1987892855 @default.
• W1968304503 cites W1988826453 @default.
• W1968304503 cites W1990997223 @default.
• W1968304503 cites W1991095764 @default.
• W1968304503 cites W1991594587 @default.
• W1968304503 cites W1993331859 @default.
• W1968304503 cites W1993356903 @default.
• W1968304503 cites W1995050609 @default.
• W1968304503 cites W1997313988 @default.
• W1968304503 cites W2000129233 @default.
• W1968304503 cites W2003202242 @default.
• W1968304503 cites W2004639676 @default.
• W1968304503 cites W2006081918 @default.
• W1968304503 cites W2008958864 @default.
• W1968304503 cites W2009554185 @default.
• W1968304503 cites W2010101404 @default.
• W1968304503 cites W2012427587 @default.
• W1968304503 cites W2017511982 @default.
• W1968304503 cites W2021846409 @default.
• W1968304503 cites W2025242285 @default.
• W1968304503 cites W2028505246 @default.
• W1968304503 cites W2036735196 @default.
• W1968304503 cites W2037617478 @default.
• W1968304503 cites W2038079185 @default.
• W1968304503 cites W2038237617 @default.
• W1968304503 cites W2041853156 @default.
• W1968304503 cites W2044772342 @default.
• W1968304503 cites W2046776262 @default.
• W1968304503 cites W2047257800 @default.
• W1968304503 cites W2047499703 @default.
• W1968304503 cites W2054095750 @default.
• W1968304503 cites W2054762568 @default.
• W1968304503 cites W2056386712 @default.
• W1968304503 cites W2057492232 @default.
• W1968304503 cites W2062549773 @default.
• W1968304503 cites W2063612820 @default.
• W1968304503 cites W2064290926 @default.
• W1968304503 cites W2065612971 @default.
• W1968304503 cites W2066633517 @default.
• W1968304503 cites W2071991978 @default.
• W1968304503 cites W2072488203 @default.
• W1968304503 cites W2076862430 @default.
• W1968304503 cites W2083588619 @default.
• W1968304503 cites W2084841223 @default.
• W1968304503 cites W2086821046 @default.
• W1968304503 cites W2088682375 @default.
• W1968304503 cites W2091229335 @default.
• W1968304503 cites W2094504975 @default.
• W1968304503 cites W2096694584 @default.
• W1968304503 cites W2104024176 @default.
• W1968304503 cites W2104783966 @default.
• W1968304503 cites W2106395967 @default.
• W1968304503 cites W2108026650 @default.
• W1968304503 cites W2118476555 @default.
• W1968304503 cites W2118983685 @default.
• W1968304503 cites W2120551209 @default.
• W1968304503 cites W2122676510 @default.
• W1968304503 cites W2123243173 @default.
• W1968304503 cites W2123969140 @default.
• W1968304503 cites W2126413227 @default.
• W1968304503 cites W2130781866 @default.
• W1968304503 cites W2131980604 @default.
• W1968304503 cites W2132991593 @default.
• W1968304503 cites W2134877456 @default.
• W1968304503 cites W2136150753 @default.
• W1968304503 cites W2140194841 @default.
• W1968304503 cites W2144178804 @default.
• W1968304503 cites W2146196612 @default.
• W1968304503 cites W2156760391 @default.
• W1968304503 cites W2162141349 @default.
• W1968304503 cites W2162505315 @default.
• W1968304503 cites W2163332110 @default.
• W1968304503 cites W2167940070 @default.
• W1968304503 cites W2188112449 @default.
• W1968304503 cites W4322701724 @default.
• W1968304503 cites W3151900777 @default.
• W1968304503 doi "https://doi.org/10.1016/j.gastrohep.2011.08.002" @default.

• next