FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968304880> ?p ?o ?g. }

• W1968304880 endingPage "1653" @default.
• W1968304880 startingPage "1645" @default.
• W1968304880 abstract "Asthmatics with overproduction of mucus that is viscous and sticky have impaired mucociliary clearance (MCC) leading to mucus plugs, and airway obstruction. Inhaled mannitol improves mucus clearance in other hypersecretory diseases. This study investigated the effect of mannitol and cough in asthmatics with mucociliary dysfunction. Seven stable asthmatics, age 52 ± 20 yr, lifelong non-smokers, without the diagnosis of bronchiectasis, with chronic cough and sputum production, treated with inhaled corticosteroids participated in the study. MCC and cough clearance (CC) was measured on 4 visits: at baseline (no cough or mannitol), with mannitol (240 and 480 mg) and cough control (no mannitol) over total 90 min using a radioaerosol technique and imaging with a gamma camera. Cough clearance was assessed after MCC by asking subjects to cough 100 times over 30 min. Premedication with eformoterol (12 μg) on all visits protected all subjects from bronchoconstriction (fall in FEV(1) > 15%) in response to mannitol. Mean (±SD) clearance over 60 min increased from 5.5 ± 5.6% at baseline and 7.3 ± 6.6% with cough control to 19.5 ± 14.6% and 26.4 ± 11.5% with 240 mg (p < 0.003) and 480 mg (p < 0.0001) of mannitol respectively. Total clearance (MCC + CC) over 90 min increased from 6.9 ± 6.5% (baseline) and 12.6 ± 8.3% without mannitol (cough control) to 34.6 ± 13.5 and 36.6 ± 10.4% with 240 and 480 mg mannitol respectively (p < 0.0001). Clearance over 90 min at baseline was not significantly different to cough control (p > 0.05). Mannitol improved clearance in all lung regions (p < 0.005). In conclusion, mannitol improved both mucociliary and cough clearance in asthmatics with mucociliary dysfunction and ineffective cough clearance. Clinical Trial registered with www.anzctr.org.au; Number ACTRN 12609001066279.aspx." @default.
• W1968304880 created "2016-06-24" @default.
• W1968304880 creator A5016235854 @default.
• W1968304880 creator A5033497816 @default.
• W1968304880 creator A5075584909 @default.
• W1968304880 creator A5088965105 @default.
• W1968304880 date "2010-11-01" @default.
• W1968304880 modified "2023-10-02" @default.
• W1968304880 title "Beneficial effect of inhaled mannitol and cough in asthmatics with mucociliary dysfunction" @default.
• W1968304880 cites W1511108850 @default.
• W1968304880 cites W1534616656 @default.
• W1968304880 cites W1859763432 @default.
• W1968304880 cites W1965797594 @default.
• W1968304880 cites W1981720530 @default.
• W1968304880 cites W1986733730 @default.
• W1968304880 cites W2000169358 @default.
• W1968304880 cites W2000228858 @default.
• W1968304880 cites W2008520655 @default.
• W1968304880 cites W2019609817 @default.
• W1968304880 cites W2021308965 @default.
• W1968304880 cites W2026279532 @default.
• W1968304880 cites W2028210174 @default.
• W1968304880 cites W2031880739 @default.
• W1968304880 cites W2037625381 @default.
• W1968304880 cites W2047755217 @default.
• W1968304880 cites W2063292211 @default.
• W1968304880 cites W2068560260 @default.
• W1968304880 cites W2101735295 @default.
• W1968304880 cites W2109481663 @default.
• W1968304880 cites W2113594634 @default.
• W1968304880 cites W2114313124 @default.
• W1968304880 cites W2126762232 @default.
• W1968304880 cites W2131792955 @default.
• W1968304880 cites W2132665778 @default.
• W1968304880 cites W2134260485 @default.
• W1968304880 cites W2143238483 @default.
• W1968304880 cites W2147684493 @default.
• W1968304880 cites W2153867520 @default.
• W1968304880 cites W2165420508 @default.
• W1968304880 cites W2167836113 @default.
• W1968304880 cites W2175665858 @default.
• W1968304880 cites W2994597783 @default.
• W1968304880 cites W4247475865 @default.
• W1968304880 doi "https://doi.org/10.1016/j.rmed.2010.05.019" @default.
• W1968304880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20576419" @default.
• W1968304880 hasPublicationYear "2010" @default.
• W1968304880 type Work @default.
• W1968304880 sameAs 1968304880 @default.
• W1968304880 citedByCount "25" @default.
• W1968304880 countsByYear W19683048802012 @default.
• W1968304880 countsByYear W19683048802013 @default.
• W1968304880 countsByYear W19683048802014 @default.
• W1968304880 countsByYear W19683048802015 @default.
• W1968304880 countsByYear W19683048802016 @default.
• W1968304880 countsByYear W19683048802017 @default.
• W1968304880 countsByYear W19683048802018 @default.
• W1968304880 countsByYear W19683048802019 @default.
• W1968304880 countsByYear W19683048802020 @default.
• W1968304880 countsByYear W19683048802021 @default.
• W1968304880 countsByYear W19683048802022 @default.
• W1968304880 crossrefType "journal-article" @default.
• W1968304880 hasAuthorship W1968304880A5016235854 @default.
• W1968304880 hasAuthorship W1968304880A5033497816 @default.
• W1968304880 hasAuthorship W1968304880A5075584909 @default.
• W1968304880 hasAuthorship W1968304880A5088965105 @default.
• W1968304880 hasBestOaLocation W19683048801 @default.
• W1968304880 hasConcept C105922876 @default.
• W1968304880 hasConcept C114682108 @default.
• W1968304880 hasConcept C126322002 @default.
• W1968304880 hasConcept C142724271 @default.
• W1968304880 hasConcept C178790620 @default.
• W1968304880 hasConcept C185592680 @default.
• W1968304880 hasConcept C18903297 @default.
• W1968304880 hasConcept C2776042228 @default.
• W1968304880 hasConcept C2776301714 @default.
• W1968304880 hasConcept C2777312293 @default.
• W1968304880 hasConcept C2777714996 @default.
• W1968304880 hasConcept C2778445172 @default.
• W1968304880 hasConcept C2780769369 @default.
• W1968304880 hasConcept C2781069245 @default.
• W1968304880 hasConcept C42219234 @default.
• W1968304880 hasConcept C71924100 @default.
• W1968304880 hasConcept C86803240 @default.
• W1968304880 hasConcept C90924648 @default.
• W1968304880 hasConceptScore W1968304880C105922876 @default.
• W1968304880 hasConceptScore W1968304880C114682108 @default.
• W1968304880 hasConceptScore W1968304880C126322002 @default.
• W1968304880 hasConceptScore W1968304880C142724271 @default.
• W1968304880 hasConceptScore W1968304880C178790620 @default.
• W1968304880 hasConceptScore W1968304880C185592680 @default.
• W1968304880 hasConceptScore W1968304880C18903297 @default.
• W1968304880 hasConceptScore W1968304880C2776042228 @default.
• W1968304880 hasConceptScore W1968304880C2776301714 @default.
• W1968304880 hasConceptScore W1968304880C2777312293 @default.
• W1968304880 hasConceptScore W1968304880C2777714996 @default.
• W1968304880 hasConceptScore W1968304880C2778445172 @default.
• W1968304880 hasConceptScore W1968304880C2780769369 @default.
• W1968304880 hasConceptScore W1968304880C2781069245 @default.

• next