Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968319144> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1968319144 endingPage "412" @default.
- W1968319144 startingPage "409" @default.
- W1968319144 abstract "Systemically administered mexiletine, an antiarrhythmic, has been shown to also possess analgesic properties in some conditions of neuropathic pain. It has been suggested that the analgesic effect of mexiletine may be derived from the action of one of its optical isomers, (+)(S)-mexiletine. In the present study, we have compared the effects of systemic (−)-(R)- and (+)-(S)-mexiletine, on chronic mechanical allodynia-like behaviour in spinally injured rats, a model of central neuropathic pain in which racemic mexiletine has been shown to be active. I.p. racemic mexiletine as well as (−)-(R)- and (+)(S)-mexiletine at 25 mg/kg all produced significant, but brief, alleviation of mechanical allodynia in a similar fashion as assessed with von-Frey hair elicited vocalization in the spinally injured rats. A slight increase in motor impairment was observed in all three groups which reached statistical significance for the racemic mexiletine and (+)-(S)-mexiletine. Our results suggest that both isomers of mexiletine contribute to the antiallodynic effect in this model of central pain." @default.
- W1968319144 created "2016-06-24" @default.
- W1968319144 creator A5018814511 @default.
- W1968319144 creator A5051728034 @default.
- W1968319144 creator A5055926195 @default.
- W1968319144 creator A5056388603 @default.
- W1968319144 date "2000-12-01" @default.
- W1968319144 modified "2023-10-16" @default.
- W1968319144 title "Lack of stereoselectivity for the antiallodynic effect of mexiletine in spinally injured rats" @default.
- W1968319144 cites W1970981800 @default.
- W1968319144 cites W1978889801 @default.
- W1968319144 cites W1981706023 @default.
- W1968319144 cites W1982939797 @default.
- W1968319144 cites W1986237413 @default.
- W1968319144 cites W1996866337 @default.
- W1968319144 cites W2009852982 @default.
- W1968319144 cites W2013979579 @default.
- W1968319144 cites W2031115386 @default.
- W1968319144 cites W2031697363 @default.
- W1968319144 cites W2037442891 @default.
- W1968319144 cites W2045274678 @default.
- W1968319144 cites W2055379023 @default.
- W1968319144 cites W2055533471 @default.
- W1968319144 cites W2060880376 @default.
- W1968319144 cites W2228931523 @default.
- W1968319144 doi "https://doi.org/10.1053/eujp.2000.0201" @default.
- W1968319144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11124013" @default.
- W1968319144 hasPublicationYear "2000" @default.
- W1968319144 type Work @default.
- W1968319144 sameAs 1968319144 @default.
- W1968319144 citedByCount "4" @default.
- W1968319144 countsByYear W19683191442022 @default.
- W1968319144 crossrefType "journal-article" @default.
- W1968319144 hasAuthorship W1968319144A5018814511 @default.
- W1968319144 hasAuthorship W1968319144A5051728034 @default.
- W1968319144 hasAuthorship W1968319144A5055926195 @default.
- W1968319144 hasAuthorship W1968319144A5056388603 @default.
- W1968319144 hasConcept C126322002 @default.
- W1968319144 hasConcept C15490471 @default.
- W1968319144 hasConcept C170493617 @default.
- W1968319144 hasConcept C2777107010 @default.
- W1968319144 hasConcept C2777561782 @default.
- W1968319144 hasConcept C2777883359 @default.
- W1968319144 hasConcept C2779245659 @default.
- W1968319144 hasConcept C2780820201 @default.
- W1968319144 hasConcept C42219234 @default.
- W1968319144 hasConcept C71924100 @default.
- W1968319144 hasConcept C98274493 @default.
- W1968319144 hasConceptScore W1968319144C126322002 @default.
- W1968319144 hasConceptScore W1968319144C15490471 @default.
- W1968319144 hasConceptScore W1968319144C170493617 @default.
- W1968319144 hasConceptScore W1968319144C2777107010 @default.
- W1968319144 hasConceptScore W1968319144C2777561782 @default.
- W1968319144 hasConceptScore W1968319144C2777883359 @default.
- W1968319144 hasConceptScore W1968319144C2779245659 @default.
- W1968319144 hasConceptScore W1968319144C2780820201 @default.
- W1968319144 hasConceptScore W1968319144C42219234 @default.
- W1968319144 hasConceptScore W1968319144C71924100 @default.
- W1968319144 hasConceptScore W1968319144C98274493 @default.
- W1968319144 hasIssue "4" @default.
- W1968319144 hasLocation W19683191441 @default.
- W1968319144 hasLocation W19683191442 @default.
- W1968319144 hasOpenAccess W1968319144 @default.
- W1968319144 hasPrimaryLocation W19683191441 @default.
- W1968319144 hasRelatedWork W1997546463 @default.
- W1968319144 hasRelatedWork W2022836457 @default.
- W1968319144 hasRelatedWork W2024991871 @default.
- W1968319144 hasRelatedWork W2034715227 @default.
- W1968319144 hasRelatedWork W2061368203 @default.
- W1968319144 hasRelatedWork W2094779980 @default.
- W1968319144 hasRelatedWork W2151482650 @default.
- W1968319144 hasRelatedWork W2807959879 @default.
- W1968319144 hasRelatedWork W3034652886 @default.
- W1968319144 hasRelatedWork W4237844480 @default.
- W1968319144 hasVolume "4" @default.
- W1968319144 isParatext "false" @default.
- W1968319144 isRetracted "false" @default.
- W1968319144 magId "1968319144" @default.
- W1968319144 workType "article" @default.