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- W1968320836 abstract "Urocortin 3 (UCN3) is strongly expressed in specific nuclei of the rodent brain, at sites distinct from those expressing urocortin 1 and urocortin 2, the other endogenous ligands of corticotropin-releasing hormone receptor type 2 (CRH-R2). To determine the physiological role of UCN3, we generated UCN3-deficient mice, in which the UCN3 open reading frame was replaced by a tau-lacZ reporter gene. By means of this reporter gene, the nucleus parabrachialis and the premammillary nucleus were identified as previously unknown sites of UCN3 expression. Additionally, the introduced reporter gene enabled the visualization of axonal projections of UCN3-expressing neurons from the superior paraolivary nucleus to the inferior colliculus and from the posterodorsal part of the medial amygdala to the principal nucleus of the bed nucleus of the stria terminalis, respectively. The examination of tau-lacZ reporter gene activity throughout the brain underscored a predominant expression of UCN3 in nuclei functionally connected to the accessory olfactory system. Male and female mice were comprehensively phenotyped but none of the applied tests provided indications for a role of UCN3 in the context of hypothalamic-pituitary-adrenocortical axis regulation, anxiety- or depression-related behavior. However, inspired by the prevalent expression throughout the accessory olfactory system, we identified alterations in social discrimination abilities of male and female UCN3 knock-out mice that were also present in male CRH-R2 knock-out mice. In conclusion, our results suggest a novel role for UCN3 and CRH-R2 related to the processing of social cues and to the establishment of social memories." @default.
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- W1968320836 date "2010-07-07" @default.
- W1968320836 modified "2023-10-17" @default.
- W1968320836 title "Urocortin 3 Modulates Social Discrimination Abilities via Corticotropin-Releasing Hormone Receptor Type 2" @default.
- W1968320836 cites W1482141418 @default.
- W1968320836 cites W1495277562 @default.
- W1968320836 cites W1531005638 @default.
- W1968320836 cites W1540969441 @default.
- W1968320836 cites W1560019823 @default.
- W1968320836 cites W1602757251 @default.
- W1968320836 cites W1633118497 @default.
- W1968320836 cites W1659705459 @default.
- W1968320836 cites W1703928389 @default.
- W1968320836 cites W1768274470 @default.
- W1968320836 cites W189183217 @default.
- W1968320836 cites W1896866869 @default.
- W1968320836 cites W1969207271 @default.
- W1968320836 cites W1971288730 @default.
- W1968320836 cites W1974849438 @default.
- W1968320836 cites W1976649034 @default.
- W1968320836 cites W1981759923 @default.
- W1968320836 cites W1984437233 @default.
- W1968320836 cites W1985821149 @default.
- W1968320836 cites W1988676093 @default.
- W1968320836 cites W1996078639 @default.
- W1968320836 cites W1996368170 @default.
- W1968320836 cites W2003392460 @default.
- W1968320836 cites W2006327345 @default.
- W1968320836 cites W2012416101 @default.
- W1968320836 cites W2014721239 @default.
- W1968320836 cites W2024117628 @default.
- W1968320836 cites W2027371926 @default.
- W1968320836 cites W2028464672 @default.
- W1968320836 cites W2028710649 @default.
- W1968320836 cites W2030392869 @default.
- W1968320836 cites W2040801939 @default.
- W1968320836 cites W2041143171 @default.
- W1968320836 cites W2041863961 @default.
- W1968320836 cites W2053655390 @default.
- W1968320836 cites W2061478482 @default.
- W1968320836 cites W2063455379 @default.
- W1968320836 cites W2065574911 @default.
- W1968320836 cites W2069186336 @default.
- W1968320836 cites W2072555553 @default.
- W1968320836 cites W2074446107 @default.
- W1968320836 cites W2075180856 @default.
- W1968320836 cites W2076219468 @default.
- W1968320836 cites W2077577252 @default.
- W1968320836 cites W2078855259 @default.
- W1968320836 cites W2082917235 @default.
- W1968320836 cites W2083254635 @default.
- W1968320836 cites W2084173546 @default.
- W1968320836 cites W2084882106 @default.
- W1968320836 cites W2084931825 @default.
- W1968320836 cites W2086241581 @default.
- W1968320836 cites W2087064986 @default.
- W1968320836 cites W2090997737 @default.
- W1968320836 cites W2092569856 @default.
- W1968320836 cites W2095646540 @default.
- W1968320836 cites W2097432914 @default.
- W1968320836 cites W2103948764 @default.
- W1968320836 cites W2108623756 @default.
- W1968320836 cites W2109635522 @default.
- W1968320836 cites W2110654827 @default.
- W1968320836 cites W2121082491 @default.
- W1968320836 cites W2126655806 @default.
- W1968320836 cites W2128655018 @default.
- W1968320836 cites W2131767872 @default.
- W1968320836 cites W2144727302 @default.
- W1968320836 cites W2151426159 @default.
- W1968320836 cites W2152345984 @default.
- W1968320836 cites W2153900484 @default.
- W1968320836 cites W2157762162 @default.
- W1968320836 cites W2160726936 @default.
- W1968320836 cites W2164671673 @default.
- W1968320836 cites W2166555967 @default.
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- W1968320836 doi "https://doi.org/10.1523/jneurosci.1049-10.2010" @default.
- W1968320836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6632482" @default.