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- W1968323513 abstract "The photodynamic action of cercosporin was assayed in various kinds of natural and artificial membranes. Cercosporin induces lipoperoxidation of liposomes, rat liver and pea internode mitochondria and microsomes, estimated both as malondialdehyde (MDA) formation and O2 consumption. Cercosporin-induced lipoperoxidation is inhibited by either singlet oxygen quenchers, free radical trapping agents or EDTA. Superoxide anion (O2−), hydrogen peroxide and hydroxyl radicals (·OH) are not involved in the actvity of cercosporin. In addition cercosporin, by chelating iron, lowers the lipoperoxidation induced by such a metal. Therefore cercosporin stimulates, through singlet oxygen production, the hydroperoxide formation but, at the same time, it inhibits the continuation of the iron-mediated free radical chain. The present results suggest that cellular lipid peroxidation has a certain relevance to toxic activity of cercosporin." @default.
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- W1968323513 date "1979-12-01" @default.
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- W1968323513 title "Lipid peroxidation induced by cercosporin as a possible determinant of its toxicity" @default.
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- W1968323513 doi "https://doi.org/10.1016/0009-2797(79)90156-x" @default.
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