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• W1968324610 abstract "Stem cells and their niches are studied in many systems, but mammalian germ stem cells (GSC) and their niches are still poorly understood. In rat testis, spermatogonia and undifferentiated Sertoli cells proliferate before puberty, but at puberty most spermatogonia enter spermatogenesis, and Sertoli cells differentiate to support this program. Thus, pre-pubertal spermatogonia might possess GSC potential and pre-pubertal Sertoli cells niche functions. We hypothesized that the different stem cell pools at pre-puberty and maturity provide a model for the identification of stem cell and niche-specific genes. We compared the transcript profiles of spermatogonia and Sertoli cells from pre-pubertal and pubertal rats and examined how these related to genes expressed in testicular cancers, which might originate from inappropriate communication between GSCs and Sertoli cells.The pre-pubertal spermatogonia-specific gene set comprised known stem cell and spermatogonial stem cell (SSC) markers. Similarly, the pre-pubertal Sertoli cell-specific gene set comprised known niche gene transcripts. A large fraction of these specifically enriched transcripts encoded trans-membrane, extra-cellular, and secreted proteins highlighting stem cell to niche communication. Comparing selective gene sets established in this study with published gene expression data of testicular cancers and their stroma, we identified sets expressed genes shared between testicular tumors and pre-pubertal spermatogonia, and tumor stroma and pre-pubertal Sertoli cells with statistic significance.Our data suggest that SSC and their niche specifically express complementary factors for cell communication and that the same factors might be implicated in the communication between tumor cells and their micro-environment in testicular cancer." @default.
• W1968324610 created "2016-06-24" @default.
• W1968324610 creator A5019366627 @default.
• W1968324610 creator A5024565466 @default.
• W1968324610 creator A5027818593 @default.
• W1968324610 creator A5033075846 @default.
• W1968324610 creator A5043968900 @default.
• W1968324610 creator A5047372645 @default.
• W1968324610 creator A5062025504 @default.
• W1968324610 creator A5081934588 @default.
• W1968324610 date "2011-01-13" @default.
• W1968324610 modified "2023-10-10" @default.
• W1968324610 title "Gene expression profiling of rat spermatogonia and Sertoli cells reveals signaling pathways from stem cells to niche and testicular cancer cells to surrounding stroma" @default.
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• W1968324610 doi "https://doi.org/10.1186/1471-2164-12-29" @default.

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