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• W1968334728 endingPage "1421" @default.
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• W1968334728 abstract "DNA-dependent protein kinase (DNA-PK) is an important nuclear enzyme which consists of a catalytic subunit known as DNA-PKcs and a regulatory component identified as the Ku autoantigen. In the present study, we surveyed 312 patients in a search for this specificity. 10 sera immunoprecipitated a large polypeptide which exactly comigrated with DNA-PKcs in SDS-PAGE. Immunoblot analysis demonstrated that this polypeptide was recognizable by a rabbit antiserum specific for DNA-PKcs. Although the patient sera did not bind to biochemically purified DNA-PKcs in immunoblots or ELISA, they were able to deplete DNA-PK catalytic activity from extracts of HeLa cells in a dose-dependent manner. We conclude that these antibodies should be useful probes for studies which aim to define the role of DNA-PK in cells. Since six sera simultaneously contained antibodies to the Ku protein, these studies suggest that relatively intact forms of DNA-PK complex act as autoantigenic particles in selected patients." @default.
• W1968334728 created "2016-06-24" @default.
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• W1968334728 date "1996-03-15" @default.
• W1968334728 modified "2023-10-13" @default.
• W1968334728 title "Autoantibodies to DNA-dependent protein kinase. Probes for the catalytic subunit." @default.
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• W1968334728 doi "https://doi.org/10.1172/jci118562" @default.
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