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• W1968335311 endingPage "244" @default.
• W1968335311 startingPage "237" @default.
• W1968335311 abstract "There has been an enormous body of literature published in the last 10 years concerning copper and PrP (prion protein). Despite this, there is still no generally accepted role for copper in the function of PrP or any real consensus as to how and to what affinity copper associates with the protein. The present review attempts to look at all the evidence for the chemistry, co-ordination and affinity of copper binding to PrP, and then looks at what effect this has on the protein. We then connect this evidence with possible roles for PrP when bound to copper. No clear conclusions can be made from the available data, but it is clear from the present review what aspects of copper association with PrP need to be re-investigated." @default.
• W1968335311 created "2016-06-24" @default.
• W1968335311 creator A5031917567 @default.
• W1968335311 creator A5091019722 @default.
• W1968335311 date "2008-02-12" @default.
• W1968335311 modified "2023-10-15" @default.
• W1968335311 title "The chemistry of copper binding to PrP: is there sufficient evidence to elucidate a role for copper in protein function?" @default.
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• W1968335311 doi "https://doi.org/10.1042/bj20071477" @default.
• W1968335311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18254729" @default.
• W1968335311 hasPublicationYear "2008" @default.
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