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• W1968339940 startingPage "153" @default.
• W1968339940 abstract "There is a statistical decline of testosterone levels in ageing men, most manifest in free testosterone. While this fall is only moderate, ageing men show clinical signs of hypogonadism (loss of muscle mass/strength, reduction in bone mass and an increase in visceral fat). This might represent not only a fall but (also) an impairment of the biological action of androgens in target organs. The first small scale studies of androgen supplement administration in ageing men were not disappointing. Anticipated risks lie with the prostate and the cardiovascular system. The risks with regard to prostate disease are often over-rated. The question remains how the segment of the ageing male population possibly benefiting from androgen supplements, can be identified. For the treatment of postmenopausal women ‘designer oestrogens’ are being developed; similarly, designer androgens retaining beneficial anabolic effects with elimination of harmful effects on the prostate and cardiovascular system, could be devised." @default.
• W1968339940 created "2016-06-24" @default.
• W1968339940 creator A5090844224 @default.
• W1968339940 date "1998-10-01" @default.
• W1968339940 modified "2023-10-17" @default.
• W1968339940 title "Endocrine aspects of ageing in the male" @default.
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• W1968339940 doi "https://doi.org/10.1016/s0303-7207(98)00182-8" @default.
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