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- W1968339996 abstract "1. The toxicokinetics of cis- and trans-tetramethrin isomers were investigated using the isolated perfused rat liver preparation.2. The concentration of cis- and trans-tetramethrin decreased rapidly in the plasma perfusate and was initially replaced by N-(hydroxymethyl)3,4,5,6-tetrahydrophthalimide (MTI) and then by 3,4,5,6-tetrahydrophthalimide (TPI). Plasma perfusate concentrations of the intact cis-isomer were higher than those of the trans-isomer. Concentrations of MTI and TPI were higher in livers treated with the trans-isomer.3. Tetramethrin and its metabolites were rapidly excreted in the bile. Bile from livers perfused with trans-isomer contained higher concentrations of parent isomer and metabolites MTI and TPI, than did bile from livers treated with the cis-isomer" @default.
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- W1968339996 date "1989-01-01" @default.
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- W1968339996 title "The Toxicokinetics of (1R,<i>Cis</i>)- and (1R,<i>Trans</i>)-Tetramethrin in the Isolated Perfused Rat Liver" @default.
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- W1968339996 doi "https://doi.org/10.3109/00498258909042290" @default.
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