Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968343003> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1968343003 endingPage "113" @default.
- W1968343003 startingPage "103" @default.
- W1968343003 abstract "The strong evolutionary conservation of the DNA methyltransferase, Dnmt2, is at odds with the absence of phenotypic defects in organisms lacking Dnmt2. The cellular processes where Dnmt2 has a role to play also remain largely undiscovered. Here we show that Dnmt2 is a part of RNA processing machinery during cellular stress. In addition to interacting with proteins involved in RNA processing and cellular stress, Dnmt2 exhibits nucleo-cytoplasmic shuttling in response to cellular stress. Normally present in the nucleus, under conditions of stress, Dnmt2 relocalises to the cytoplasmic Stress Granules and RNA processing bodies. Surprisingly, for a DNA methyltransferase, knockout of which showed no phenotypic defects in several species, our results show that transient transfection of Dnmt2 in mammalian cells causes cell lethality. Interestingly, Dnmt2 overexpression altered the expression of several genes involved in viral infection. Taking into consideration its recently identified role in retrotransposon silencing, the role of Dnmt2 in stress granules could represent a primitive cellular defense mechanism against viral infection." @default.
- W1968343003 created "2016-06-24" @default.
- W1968343003 creator A5044469928 @default.
- W1968343003 creator A5054698548 @default.
- W1968343003 creator A5075457398 @default.
- W1968343003 date "2011-01-01" @default.
- W1968343003 modified "2023-09-30" @default.
- W1968343003 title "The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress" @default.
- W1968343003 cites W1536529218 @default.
- W1968343003 cites W1899339598 @default.
- W1968343003 cites W1964628768 @default.
- W1968343003 cites W1982273994 @default.
- W1968343003 cites W1989538298 @default.
- W1968343003 cites W1993209540 @default.
- W1968343003 cites W2003235222 @default.
- W1968343003 cites W2005311687 @default.
- W1968343003 cites W2006841357 @default.
- W1968343003 cites W2007085897 @default.
- W1968343003 cites W2010785923 @default.
- W1968343003 cites W2011221870 @default.
- W1968343003 cites W2013482681 @default.
- W1968343003 cites W2018517017 @default.
- W1968343003 cites W2029185068 @default.
- W1968343003 cites W2030161653 @default.
- W1968343003 cites W2036300762 @default.
- W1968343003 cites W2069833151 @default.
- W1968343003 cites W2092985359 @default.
- W1968343003 cites W2095910329 @default.
- W1968343003 cites W2101825447 @default.
- W1968343003 cites W2109020270 @default.
- W1968343003 cites W2112523914 @default.
- W1968343003 cites W2114717251 @default.
- W1968343003 cites W2115521704 @default.
- W1968343003 cites W2121369682 @default.
- W1968343003 cites W2134530067 @default.
- W1968343003 cites W2143069387 @default.
- W1968343003 cites W2148078543 @default.
- W1968343003 cites W2156839509 @default.
- W1968343003 cites W2168771720 @default.
- W1968343003 cites W2169825756 @default.
- W1968343003 doi "https://doi.org/10.4161/epi.6.1.13418" @default.
- W1968343003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20864816" @default.
- W1968343003 hasPublicationYear "2011" @default.
- W1968343003 type Work @default.
- W1968343003 sameAs 1968343003 @default.
- W1968343003 citedByCount "54" @default.
- W1968343003 countsByYear W19683430032012 @default.
- W1968343003 countsByYear W19683430032013 @default.
- W1968343003 countsByYear W19683430032014 @default.
- W1968343003 countsByYear W19683430032015 @default.
- W1968343003 countsByYear W19683430032016 @default.
- W1968343003 countsByYear W19683430032017 @default.
- W1968343003 countsByYear W19683430032018 @default.
- W1968343003 countsByYear W19683430032019 @default.
- W1968343003 countsByYear W19683430032020 @default.
- W1968343003 countsByYear W19683430032021 @default.
- W1968343003 countsByYear W19683430032022 @default.
- W1968343003 countsByYear W19683430032023 @default.
- W1968343003 crossrefType "journal-article" @default.
- W1968343003 hasAuthorship W1968343003A5044469928 @default.
- W1968343003 hasAuthorship W1968343003A5054698548 @default.
- W1968343003 hasAuthorship W1968343003A5075457398 @default.
- W1968343003 hasBestOaLocation W19683430031 @default.
- W1968343003 hasConcept C104317684 @default.
- W1968343003 hasConcept C166703698 @default.
- W1968343003 hasConcept C54355233 @default.
- W1968343003 hasConcept C67705224 @default.
- W1968343003 hasConcept C86803240 @default.
- W1968343003 hasConcept C95444343 @default.
- W1968343003 hasConceptScore W1968343003C104317684 @default.
- W1968343003 hasConceptScore W1968343003C166703698 @default.
- W1968343003 hasConceptScore W1968343003C54355233 @default.
- W1968343003 hasConceptScore W1968343003C67705224 @default.
- W1968343003 hasConceptScore W1968343003C86803240 @default.
- W1968343003 hasConceptScore W1968343003C95444343 @default.
- W1968343003 hasIssue "1" @default.
- W1968343003 hasLocation W19683430031 @default.
- W1968343003 hasLocation W19683430032 @default.
- W1968343003 hasOpenAccess W1968343003 @default.
- W1968343003 hasPrimaryLocation W19683430031 @default.
- W1968343003 hasRelatedWork W1991523530 @default.
- W1968343003 hasRelatedWork W2002128513 @default.
- W1968343003 hasRelatedWork W2009966535 @default.
- W1968343003 hasRelatedWork W2020824267 @default.
- W1968343003 hasRelatedWork W2031436818 @default.
- W1968343003 hasRelatedWork W2057739827 @default.
- W1968343003 hasRelatedWork W2075354549 @default.
- W1968343003 hasRelatedWork W2171277769 @default.
- W1968343003 hasRelatedWork W2894391419 @default.
- W1968343003 hasRelatedWork W2092874662 @default.
- W1968343003 hasVolume "6" @default.
- W1968343003 isParatext "false" @default.
- W1968343003 isRetracted "false" @default.
- W1968343003 magId "1968343003" @default.
- W1968343003 workType "article" @default.